ArticleTransplantation2012
T-cell-based immunosuppressive therapy inhibits the development of natural antibodies in infant baboons.
Article in Transplantation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Xenotransplantation: Promises and Perils.Annual review of medicine · 2026Review
- Contributions of Europeans to Xenotransplantation Research: 1. Pig Organ Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2025Review
- The Evolution of Immunosuppressive Therapy in Pig-to-Nonhuman Primate Organ Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- The potential of cardiac xenotransplantation for management of infants with complex congenital heart disease.Translational pediatrics · 2023Review
- Cardiac xenotransplantation: from concept to clinic.Cardiovascular research · 2023Review
- Will previous palliative surgery for congenital heart disease be detrimental to subsequent pig heart xenotransplantation?Transplant immunology · 2022Article
- The potential of genetically engineered pig heart transplantation in infants with complex congenital heart disease.Pediatric transplantation · 2022Review
- A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model.Scientific reports · 2022Article
- The immune system in infants: Relevance to xenotransplantation.Pediatric transplantation · 2020Review
- Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs.Xenotransplantation · 2019Article
- The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome?Pediatric cardiology · 2019Review
- An approach to induction of tolerance to pig cardiac xenografts in neonates.Xenotransplantation · 2018Review
- Modifying the sugar icing on the transplantation cake.Glycobiology · 2016Review
- Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs.Xenotransplantation · 2016Article
- Immunobiological barriers to xenotransplantation.International journal of surgery (London, England) · 2015Review
- Immunological challenges and therapies in xenotransplantation.Cold Spring Harbor perspectives in medicine · 2014Review
- Is there a correlation between anti-pig antibody levels in humans and geographic location during childhood?Transplantation · 2013Article
- Are there advantages in the use of specific pathogen-free baboons in pig organ xenotransplantation models?XenotransplantationArticle
- Minimal effect of bortezomib in reducing anti-pig antibodies in human leukocyte antigen-sensitized patients: a pilot study.XenotransplantationArticle
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundWe set out to determine whether B-cell tolerance to A/B-incompatible alloantigens and pig xenoantigens could be achieved in infant baboons.
methodsArtery patch grafts were implanted in the abdominal aorta in 3-month-old baboons using A/B-incompatible (AB-I) allografts or wild-type pig xenografts (pig). Group 1 (Gp1) (controls, n=6) received no immunosuppressive therapy (IS) and no graft. Gp2 (n=2) received an AB-I or pig graft but no IS. Gp3 received AB-I grafts+IS (Gp3A: n=2) or pig grafts+IS (Gp3B: n=2). IS consisted of ATG, anti-CD154mAb, and mycophenolate mofetil until age 8 to 12 months. Gp4 (n=2) received IS only but no graft.
resultsIn Gp1, anti-A/B and cytotoxic anti-pig immunoglobulin-M increased steadily during the first year. Gp2 became sensitized to donor-specific AB-I or pig antigens within 2 weeks. Gp3 and Gp4 infants that received anti-CD154mAb made no or minimal anti-A/B and anti-pig antibodies while receiving IS. DISCUSSION: The production of natural anti-A/B and anti-pig antibodies was inhibited by IS with anti-CD154mAb, even in the absence of an allograft or xenograft, suggesting that natural antibodies may not be entirely T-cell independent. These data are in contrast to clinical experience with AB-I allotransplantation in infants, who cease producing only donor-specific antibodies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.