ArticleWorld journal of urology2013
Preoperative sex steroids are significant predictors of early biochemical recurrence after radical prostatectomy.
Article in World journal of urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Low Testosterone Levels and Grade Group Progression Among Localized Prostate Cancer Patients on Active Surveillance: A Retrospective Cohort Study.The Journal of urology · 2026Article
- Preoperative high serum total testosterone levels predict preserved postoperative sexual function in patients after nerve-sparing robot-assisted radical prostatectomy.International journal of urology : official journal of the Japanese Urological Association · 2024Article
- Longer time to testosterone recovery impacts favorably on outcomes for prostate cancer following androgen deprivation and radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- Serum testosterone and prostate cancer in men with germlineBJUI compass · 2023Article
- Review
- European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction.Sexual medicine · 2020Review
- The Role of Testosterone Therapy in the Setting of Prostate Cancer.Current urology reports · 2018Review
- Preoperative Plasma Levels of Total Testosterone Associated with High Grade Pathology-Detected Prostate Cancer: Preliminary Results of a Prospective Study in a Contemporary Cohort of Patients.Current urology · 2017Article
- Article
- Testosterone therapy and prostate cancer.Translational andrology and urology · 2016Review
- Testosterone Therapy Among Prostate Cancer Survivors.Sexual medicine reviews · 2016Review
- Testosterone Replacement Therapy and Prostate Cancer Incidence.The world journal of men's health · 2015Review
- Preoperative low serum testosterone is associated with high-grade prostate cancer and an increased Gleason score upgrading.Prostate cancer and prostatic diseases · 2015Article
- Preoperative Serum Sex Hormone-Binding Globulin Level Is an Independent Predictor of Biochemical Outcome After Radical Prostatectomy.Medicine · 2015Observational
- Circulating sex steroids and prostate cancer: introducing the time-dependency theory.World journal of urology · 2013Article
- Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans.Scientific reports · 2013Article
- Normal preoperative endogenous testosterone levels predict prostate cancer progression in elderly patients after radical prostatectomy.Therapeutic advances in urologyArticle
- Narrative review of Mediterranean diet in Cilento: longevity and potential prevention for prostate cancer.Therapeutic advances in urologyArticle
- Biochemical recurrence after radical prostatectomy: Current status of its use as a treatment endpoint and early management strategies.Indian journal of urology : IJU : journal of the Urological Society of IndiaReview
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe sought the association of preoperative serum total testosterone (tT), hypogonadism, 17β estradiol (E2), and sex hormone-binding globulin (SHBG) with early biochemical recurrence (BCR) after radical prostatectomy (RP).
methodsSex steroids were assessed the day before surgery (7-11 a.m.) in a cohort of 605 patients with a median follow-up of 24 months following RP. Cox regression models tested the association between predictors [including age, body mass index (BMI), prostate-specific antigen (PSA), clinical stage, biopsy Gleason scores, tT, hypogonadism, E2, and SHBG] and early BCR (defined as a PSA ≥ 0.1 ng/ml that occurred within 24 months after RP).
resultsEarly BCR was found in 34 (5.6 %) patients. Patients with BCR did not differ in terms of age, BMI, serum PSA, tT, E2, and SHBG levels, rate of hypogonadism, and clinical stage as compared with those without BCR (all p ≥ 0.05). Conversely, patients with BCR showed a greater prevalence of biopsy Gleason scores ≥4 + 3 (all p ≤ 0.001). At multivariable Cox regression analysis, tT [hazard ratio (HR): 1.43; p = 0.03] E2 (HR: 1.05; p = 0.04), SHBG (HR: 1.29; p = 0.02), and biopsy Gleason scores equal to 4 + 3 (HR: 3.37; p = 0.04) and ≥8 (HR: 20.06; p < 0.001) achieved independent predictor status for early BCR. Conversely, no significant associations were found for all the other predictors.
conclusionsCurrent findings show that preoperative serum sex steroids are independent predictors of early BCR in a homogeneous, large cohort of nonscreened patients treated with RP.
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