ReviewCardiovascular research2012
Cardioprotection during cardiac surgery.
Review in Cardiovascular research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02471001 (Coronary Sinus Blood Isoflurane Concentration in Patients Undergoing Heart Surgery), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Coronary Sinus Blood Isoflurane Concentration in Patients Undergoing Heart Surgery
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Remote ischaemic preconditioning for coronary artery bypass grafting (with or without valve surgery).The Cochrane database of systematic reviews · 2017Pooled it
- Aspirin Use Prior to Coronary Artery Bypass Grafting Surgery: a Systematic Review.Current cardiology reports · 2017Pooled it
- Can heartbeat recovery be improved with terminal non-cardioplegic warm blood perfusion prior to aortic unclamping in single-clamp technique coronary artery bypass surgery? A randomized controlled trial.Journal of cardiothoracic surgery · 2024Trial
- Trial
- Modified Glucose-Insulin-Potassium Regimen Provides Cardioprotection With Improved Tissue Perfusion in Patients Undergoing Cardiopulmonary Bypass Surgery.Journal of the American Heart Association · 2020Trial
- Pretreatment with glucose-insulin-potassium improves ventricular performances after coronary artery bypass surgery: a randomized controlled trial.Journal of clinical monitoring and computing · 2020Trial
- The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery.Brazilian journal of cardiovascular surgery · 2019Trial
- Comparison of Warm Blood Cardioplegia Delivery With or Without the Use of a Roller Pump.The journal of extra-corporeal technology · 2015Trial
- The Effect of Remote Ischemic Conditioning and Glyceryl Trinitrate on Perioperative Myocardial Injury in Cardiac Bypass Surgery Patients: Rationale and Design of the ERIC-GTN Study.Clinical cardiology · 2015Trial
- Cardioplegia practices in pediatric cardiovascular surgery: Survey across Asia, Europe, and North America.JTCVS open · 2026Article
- Development and external validation of a machine learning model based on preoperative nutritional status for predicting acute kidney injury after coronary artery bypass grafting.Frontiers in nutrition · 2026Article
- Effect of sevoflurane on hemodynamic response during cardiopulmonary bypass in cardiac surgery patients: A randomized controlled trial.Journal of cardiovascular and thoracic research · 2025Article
- Article
- Article
- Article
- Myocardial Infarction with Non-obstructive Coronary Arteries Complicated by a Ventricular Septal Rupture: The Challenge of Achieving Hemodynamic Stability Using Impella Devices.Internal medicine (Tokyo, Japan) · 2024Article
- Cardioprotection in cardiovascular surgery.Basic research in cardiology · 2024Review
- Development and validation of a machine learning predictive model for perioperative myocardial injury in cardiac surgery with cardiopulmonary bypass.Journal of cardiothoracic surgery · 2024Article
- Cardioprotective Efficacy of Sevoflurane in Patients With Rheumatic Heart Disease Undergoing Heart Valve Surgery Under Cardiopulmonary Bypass.Journal of the Saudi Heart Association · 2024Article
- Dexmedetomidine postconditioning attenuates myocardial ischemia/reperfusion injury by activating the Nrf2/Sirt3/SOD2 signaling pathway in the rats.Redox report : communications in free radical research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Coronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide. For a large number of patients with CHD, coronary artery bypass graft (CABG) surgery remains the preferred strategy for coronary revascularization. Over the last 10 years, the number of high-risk patients undergoing CABG surgery has increased significantly, resulting in worse clinical outcomes in this patient group. This appears to be related to the ageing population, increased co-morbidities (such as diabetes, obesity, hypertension, stroke), concomitant valve disease, and advances in percutaneous coronary intervention which have resulted in patients with more complex coronary artery disease undergoing surgery. These high-risk patients are more susceptible to peri-operative myocardial injury and infarction (PMI), a major cause of which is acute global ischaemia/reperfusion injury arising from inadequate myocardial protection during CABG surgery. Therefore, novel therapeutic strategies are required to protect the heart in this high-risk patient group. In this article, we review the aetiology of PMI during CABG surgery, its diagnosis and clinical significance, and the endogenous and pharmacological therapeutic strategies available for preventing it. By improving cardioprotection during CABG surgery, we may be able to reduce PMI, preserve left ventricular systolic function, and reduce morbidity and mortality in these high-risk patients with CHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.