ArticleNeuroImage2012
Multifaceted genomic risk for brain function in schizophrenia.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Brain function, structure and genomic data are linked but show different sensitivity to duration of illness and disease stage in schizophrenia.NeuroImage. Clinical · 2019Article
- A framework for linking resting-state chronnectome/genome features in schizophrenia: A pilot study.NeuroImage · 2019Article
- A kernel machine method for detecting higher order interactions in multimodal datasets: Application to schizophrenia.Journal of neuroscience methods · 2018Article
- A Schizophrenia-Related Genetic-Brain-Cognition Pathway Revealed in a Large Chinese Population.EBioMedicine · 2018Article
- Creation of a myosin Va-TAP-tagged mouse and identification of potential myosin Va-interacting proteins in the cerebellum.Cytoskeleton (Hoboken, N.J.) · 2018Article
- Neuroimaging genomics in psychiatry-a translational approach.Genome medicine · 2017Review
- A robust sparse-modeling framework for estimating schizophrenia biomarkers from fMRI.Journal of neuroscience methods · 2017Article
- Multivariate Genetic Correlates of the Auditory Paired Stimuli-Based P2 Event-Related Potential in the Psychosis Dimension From the BSNIP Study.Schizophrenia bulletin · 2016Article
- SchizConnect: Mediating neuroimaging databases on schizophrenia and related disorders for large-scale integration.NeuroImage · 2016Article
- Article
- Genetic markers of white matter integrity in schizophrenia revealed by parallel ICA.Frontiers in human neuroscience · 2015Article
- An introductory review of parallel independent component analysis (p-ICA) and a guide to applying p-ICA to genetic data and imaging phenotypes to identify disease-associated biological pathways and systems in common complex disorders.Frontiers in genetics · 2015Review
- Interaction effect between handedness and CNTNAP2 polymorphism (rs7794745 genotype) on voice-specific frontotemporal activity in healthy individuals: an fMRI study.Frontiers in behavioral neuroscience · 2015Article
- The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.Brain imaging and behavior · 2014Review
- Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Association of GRM3 polymorphism with white matter integrity in schizophrenia.Schizophrenia research · 2014Article
- Recognition of facial emotion and affective prosody in children with ASD (+ADHD) and their unaffected siblings.European child & adolescent psychiatry · 2014Article
- Three-way parallel independent component analysis for imaging genetics using multi-objective optimization.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2014Article
- The rise of large-scale imaging studies in psychiatry.GigaScience · 2014Review
- A review of multivariate analyses in imaging genetics.Frontiers in neuroinformatics · 2014Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Recently, deriving candidate endophenotypes from brain imaging data has become a valuable approach to study genetic influences on schizophrenia (SZ), whose pathophysiology remains unclear. In this work we utilized a multivariate approach, parallel independent component analysis, to identify genomic risk components associated with brain function abnormalities in SZ. 5157 candidate single nucleotide polymorphisms (SNPs) were derived from genome-wide array based on their possible connections with SZ and further investigated for their associations with brain activations captured with functional magnetic resonance imaging (fMRI) during a sensorimotor task. Using data from 92 SZ patients and 116 healthy controls, we detected a significant correlation (r=0.29; p=2.41 × 10(-5)) between one fMRI component and one SNP component, both of which significantly differentiated patients from controls. The fMRI component mainly consisted of precentral and postcentral gyri, the major activated regions in the motor task. On average, higher activation in these regions was observed in participants with higher loadings of the linked SNP component, predominantly contributed to by 253 SNPs. 138 identified SNPs were from known coding regions of 100 unique genes. 31 identified SNPs did not differ between groups, but moderately correlated with some other group-discriminating SNPs, indicating interactions among alleles contributing toward elevated SZ susceptibility. The genes associated with the identified SNPs participated in four neurotransmitter pathways: GABA receptor signaling, dopamine receptor signaling, neuregulin signaling and glutamate receptor signaling. In summary, our work provides further evidence for the complexity of genomic risk to the functional brain abnormality in SZ and suggests a pathological role of interactions between SNPs, genes and multiple neurotransmitter pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.