ArticleVeterinary research2012
Immunohistochemical investigation of Foxp3 expression in the intestine in healthy and diseased dogs.
Article in Veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Optimized monoclonal antibody panel for accurate immunohistochemical detection of haematopoietic cell populations in animal species.BMC veterinary research · 2026Article
- Betaine and L-Carnitine Synergistically Influence the Metabolome and Immune Response in Dogs.Animals : an open access journal from MDPI · 2024Article
- Single cell transcriptomic analysis of the canine duodenum in chronic inflammatory enteropathy and health.Frontiers in immunology · 2024Article
- Impact of supplementation with dihydroxylated vitamin DPorcine health management · 2023Article
- Elucidating the Role of Innate and Adaptive Immune Responses in the Pathogenesis of Canine Chronic Inflammatory Enteropathy-A Search for Potential Biomarkers.Animals : an open access journal from MDPI · 2022Review
- Short-Chain and Total Fatty Acid Profile of Faeces or Plasma as Predictors of Food-Responsive Enteropathy in Dogs: A Preliminary Study.Animals : an open access journal from MDPI · 2021Article
- What are the potential biomarkers that should be considered in diagnosing and managing canine chronic inflammatory enteropathies?Open veterinary journal · 2021Review
- Expansion of T regulatory lymphocytes by murine bone marrow dendritic cells previously stimulated with Anisakis simplex larval antigens.Memorias do Instituto Oswaldo Cruz · 2021Article
- Immunopathogenesis of canine chronic ulcerative stomatitis.PloS one · 2020Article
- Distinct Features of Canine Non-conventional CD4Frontiers in immunology · 2019Article
- Article
- Clinical utility of currently available biomarkers in inflammatory enteropathies of dogs.Journal of veterinary internal medicine · 2018Review
- Genome-wide association studies of inflammatory bowel disease in German shepherd dogs.PloS one · 2018Article
- Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research.The AAPS journal · 2017Review
- Zoonotic intestinal helminths interact with the canine immune system by modulating T cell responses and preventing dendritic cell maturation.Scientific reports · 2017Article
- Article
- EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS.Journal of veterinary medicine and research · 2014Article
- Toxocara canis: molecular basis of immune recognition and evasion.Veterinary parasitology · 2013Article
- Phenotypic characterization of canine intestinal intraepithelial lymphocytes in dogs with inflammatory bowel disease.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal immune regulation including development of oral tolerance is of great importance for the maintenance of intestinal homeostasis. Concerning this, regulatory T cells (Tregs) occupy a pivotal role in cell-mediated immunosuppression. Dysregulation of mucosal immunology leading to an abnormal interaction with commensal bacteria is suggested to play a key role in the pathogenesis of Inflammatory Bowel Disease (IBD) in men and dogs. The aim of this study was to characterise the expression of Foxp3 in the normal canine gut of 18 dogs (mean age: 6.03 years), in 16 dogs suffering from IBD (mean age: 5.05 years), and of 6 dogs with intestinal nematode infection (mean age: 0.87 years) using immunohistochemistry. In the duodenum, Tregs in healthy dogs declined from villi (median: 10.67/62 500 μm2) to crypts (median: 1.89/62 500 μm2). Tregs were further increased in the villi of middle-aged dogs (median: 18.92/62 500 μm2) in contrast to juvenile (median: 3.50/62 500 μm2) and old (median: 9.56/62 500 μm2) individuals. Compared to healthy controls, animals suffering from IBD revealed reduced numbers of Tregs in duodenal villi (median: 4.13/62 500 μm2). Dogs with intestinal nematode infection displayed increased numbers of Tregs (median: 21.06/62 500 μm2) compared to healthy animals.Age-related changes indicate a progressive establishment of oral tolerance and immunosenescence in the canine elderly. The results further suggest that a defect in Treg homeostasis may be involved in the pathogenesis of canine IBD. In contrast, increased numbers of Tregs in the duodenum may be due to nematode infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.