ReviewTissue engineering. Part B, Reviews2012
Bisphosphonate-based strategies for bone tissue engineering and orthopedic implants.
Review in Tissue engineering. Part B, Reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- An innovative hierarchical porous oxide surface with enhanced surface area for promoting early-stage bone regeneration potential.Journal of materials science. Materials in medicine · 2026Article
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Development of a Rifapentine-Loaded Alendronate-Conjugated PLGA-PEG Nanosystem: A Novel Bone-Targeted Strategy for Osteoarticular Tuberculosis Treatment with Enhanced Drug Delivery and Bone Regeneration.International journal of nanomedicine · 2025Article
- Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion.Bioactive materials · 2024Article
- Ångstrom-scale gold particles loaded with alendronate via alpha-lipoic acid alleviate bone loss in osteoporotic mice.Journal of nanobiotechnology · 2024Article
- Bisphosphonate-incorporated coatings for orthopedic implants functionalization.Materials today. Bio · 2023Review
- Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials.Materials (Basel, Switzerland) · 2023Review
- Lipid Nanoparticles and Liposomes for Bone Diseases Treatment.Biomedicines · 2022Review
- Bone targeting antioxidative nano-iron oxide for treating postmenopausal osteoporosis.Bioactive materials · 2022Article
- New Insights into Amino-Functionalization of Magnetic Nanoplatelets with Silanes and Phosphonates.Nanomaterials (Basel, Switzerland) · 2022Article
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Design of 3D Scaffolds for Hard Tissue Engineering: From Apatites to Silicon Mesoporous Materials.Pharmaceutics · 2021Review
- Histomorphometric Evaluation of Peri-Implant Bone Response to Intravenous Administration of Zoledronate (ZometaMaterials (Basel, Switzerland) · 2020Article
- Facile fabrication of the zoledronate-incorporated coating on magnesium alloy for orthopaedic implants.Journal of orthopaedic translation · 2020Review
- Phosphate functionalization and enzymatic calcium mineralization synergistically enhance oligo[poly(ethylene glycol) fumarate] hydrogel osteoconductivity for bone tissue engineering.Journal of biomedical materials research. Part A · 2020Article
- Anti-Tumor Effects of Low Dose Zoledronate on Lung Cancer-Induced Spine Metastasis.Journal of clinical medicine · 2019Article
- Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw.Materials (Basel, Switzerland) · 2019Article
- Low-dose zoledronate for the treatment of bone metastasis secondary to prostate cancer.Cancer cell international · 2019Article
- Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions.Scientific reports · 2018Article
- Self-powered therapeutic release from conducting polymer/graphene oxide films on magnesium.Nanomedicine : nanotechnology, biology, and medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphosphonates (BPs) are a group of well-established drugs that are applied in the development of metabolic bone disorder-related therapies. There is increasing interest also in the application of BPs in the context of bone tissue engineering, which is the topic of this review, in which an extensive overview of published studies on the development and applications of BPs-based strategies for bone regeneration is provided with special focus on the rationale for the use of different BPs in three-dimensional (3D) bone tissue scaffolds. The different alternatives that are investigated to address the delivery and sustained release of these therapeutic drugs in the nearby tissues are comprehensively discussed, and the most significant published approaches on bisphosphonate-conjugated drugs in multifunctional 3D scaffolds as well as the role of BPs within coatings for the improved fixation of orthopedic implants are presented and critically evaluated. Finally, the authors' views regarding the remaining challenges in the fields and directions for future research efforts are highlighted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.