ArticleBMC musculoskeletal disorders2012
Effect of local zoledronate on implant osseointegration in a rat model.
Article in BMC musculoskeletal disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 45 citations in OpenAlex.
- Therapeutic Efficacy of an Erythromycin-Loaded Coaxial Nanofiber Coating in a Rat Model ofInternational journal of molecular sciences · 2024Article
- Bisphosphonate-incorporated coatings for orthopedic implants functionalization.Materials today. Bio · 2023Review
- Zoledronic Acid Implant Coating Results in Local Medullary Bone Growth.Molecular pharmaceutics · 2022Article
- Antibiotic-loaded amphora-shaped pores on a titanium implant surface enhance osteointegration and prevent infections.Bioactive materials · 2021Article
- Facile distribution of an alkaline microenvironment improves human bone marrow mesenchymal stem cell osteogenesis on a titanium surface through the ITG/FAK/ALP pathway.International journal of implant dentistry · 2021Article
- Local and Systemic In Vivo Responses to Osseointegrative Titanium Nanotube Surfaces.Nanomaterials (Basel, Switzerland) · 2021Article
- Effect of low-level laser therapy and zoledronic acid on bone repair process.Lasers in medical science · 2019Article
- Effects of ultraviolet treatment and alendronate immersion on osteoblast-like cells and human gingival fibroblasts cultured on titanium surfaces.Scientific reports · 2019Article
- Zoledronate induces cell cycle arrest and differentiation by upregulating p21 in mouse MC3T3-E1 preosteoblasts.International journal of medical sciences · 2019Article
- Local delivery of zoledronate from a poly (d,l-lactide)-coating increases fixation of hydroxy-coated implants.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Guided bone regeneration with local zoledronic acid and titanium barrier: An experimental study.Experimental and therapeutic medicine · 2016Article
- Local delivery of zoledronate from a poly (D,L-lactide)-Coating increases fixation of press-fit implants.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Local inhibition of 5-lipoxygenase enhances bone formation in a rat model.Bone & joint research · 2013Article
- Influence of statins locally applied from orthopedic implants on osseous integration.BMC musculoskeletal disorders · 2012Article
- Peri-implant and systemic effects of high-/low-affinity bisphosphonate-hydroxyapatite composite coatings in a rabbit model with peri-implant high bone turnover.BMC musculoskeletal disorders · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn implant coating with poly(D, L-lactide) (PDLLA) releasing incorporated zoledronic acid (ZOL) has already proven to positively effect osteoblasts, to inhibit osteoclasts and to accelerate fracture healing. Aim of this study was to investigate the release kinetics of the chosen coating and the effect of different concentrations of ZOL locally released from this coating on the osseointegration of implants.
methodsFor release kinetics the release of C14-labled ZOL out of the coating was monitored over a period of six weeks in vitro. For testing the osseointegration, titanium Kirschner wires were implanted into the medullary canal of right femurs of 100 Sprague Dawley rats. The animals were divided into five groups receiving implants either uncoated or coated with PDLLA, PDLLA/ZOL low (1.2% w/w) or PDLLA/ZOL high (2% w/w). Additionally, a group with uncoated implants received ZOL intravenously (i.v.). After 56 days animals were sacrificed, femurs dissected and either strength of fixation or histological bone/implant contacts and newly formed bone around the implants were determined.
resultsRelease kinetics revealed an initial peak in the release of C14-ZOL with a slight further progression over the following weeks. There was no significant enhancement of osseointegration for both groups who received ZOL-coated implants or ZOL i.v. compared to the controls in biomechanical or histological analyses, except for a significant raise in strength of fixation of ZOL i.v. versus PDLLA.
conclusionsEven though the investigated local ZOL application did not enhance the osseointegration of the implant, the findings might support its application in fracture treatment, since fracture stabilization devices are often explanted after consolidation.
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