SynthesisBMC public health2012
Relative risk of renal disease among people living with HIV: a systematic review and meta-analysis.
Synthesis in BMC public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Microalbuminuria among HIV/AIDS patients in Africa: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Pooled it
- HIV treatment simplification to elvitegravir/cobicistat/emtricitabine/tenofovir disproxil fumarate (E/C/F/TDF) plus darunavir: a pharmacokinetic study.AIDS research and therapy · 2017Trial
- Impact of SGLT2 Inhibitors on Kidney Function Among People With HIV: A US Prospective Multisite Study.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Kidney dysfunction and its associated factors among people living with HIV on antiretroviral therapy in rural Rwanda: a cross-sectional study.BMC infectious diseases · 2026Article
- Prevalence and determinants of chronic kidney disease among HIV/AIDS patients in selected governmental hospitals at Addis Ababa, Ethiopia: a retrospective cross-sectional study.BMC infectious diseases · 2025Article
- Burden of heat stress on residual work capacity among farmers living with chronic HIV in Siaya county, Kenya: a longitudinal observational study protocol.BMC public health · 2025Observational
- Remodeling of immune system functions by extracellular vesicles.Frontiers in immunology · 2025Article
- Higher prevalence of kidney function impairment among older people living with HIV in Uganda.BMC nephrology · 2024Article
- The epidemiology of HIV/AIDS and the use of antiretroviral therapy in Korea: a narrative review.Ewha medical journal · 2024Review
- Higher prevalence of kidney function impairment among older people living with HIV in Uganda.Research square · 2024Article
- Prevalence and Risk Factors for Renal Insufficiency among Adults Living with HIV in Tanzania: Results from a Cross-Sectional Study in 2020-2021.Healthcare (Basel, Switzerland) · 2024Article
- Kidney function in healthcare clients in Khayelitsha, South Africa: Routine laboratory testing and results reflect distinct healthcare experiences by age for healthcare clients with and without HIV.PLOS global public health · 2024Article
- A BAYESIAN DECISION FRAMEWORK FOR OPTIMIZING SEQUENTIAL COMBINATION ANTIRETROVIRAL THERAPY IN PEOPLE WITH HIV.The annals of applied statistics · 2023Article
- Polypharmacy and health related quality of life among older adults on antiretroviral therapy in a tertiary hospital in Tanzania: a hospital-based cross-sectional study.BMC infectious diseases · 2023Article
- A Systematic Review Exploring the Range of Renal Complications of Human Immunodeficiency Virus.Cureus · 2023Review
- Article
- "It's a burden, it's a nuisance. I wish I didn't have these other ailments": a qualitative exploration of comorbidities management among older people living with HIV who use drugs in Vancouver, British Columbia.Journal of the International AIDS Society · 2021Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntiretroviral therapy (ART) has substantially decreased mortality and HIV-related morbidity. However, other morbidities appear to be more common among PLHIV than in the general population. This study aimed to estimate the relative risk of renal disease among people living with HIV (PLHIV) compared to the HIV-uninfected population.
methodsWe conducted a systematic review and meta-analysis of relative risks of renal disease among populations of PLHIV reported in studies from the peer-reviewed literature. We searched Medline for relevant journal articles published before September 2010, yielding papers published during or after 2002. We also searched conference proceedings of the International AIDS Society (IAS) and Conference on Retroviruses and Opportunistic Infections (CROI) prior to and including 2010. Eligible studies were observational studies reporting renal disease defined as acute or chronic reduced renal function with glomerular filtration rate less than or equal to 60 ml/min/1.73 m2 among HIV-positive adults. Pooled relative risks were calculated for various groupings, including class of ART drugs administered.
resultsThe overall relative risk of renal disease was 3.87 (95% CI: 2.85-6.85) among HIV-infected people compared to HIV-uninfected people. The relative risk of renal disease among people with late-stage HIV infection (AIDS) was 3.32 (1.86-5.93) compared to other PLHIV. The relative risk of renal disease among PLHIV who were receiving antiretroviral therapy (ART) was 0.54 (0.29-0.99) compared to treatment-naïve PLHIV; the relative risk of renal disease among PLHIV who were treated with tenofovir was 1.56 (0.83-2.93) compared to PLHIV who were treated with non-tenofovir therapy. The risk of renal disease was also found to significantly increase with age.
conclusionPLHIV are at increased risk of renal disease, with greater risk at later stages of infection and at older ages. ART prolongs survival and decreases the risk of renal disease. However, less reduction in renal disease risk occurs for Tenofovir-containing ART than for other regimens.
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