Evidence map›Paper›PMID 22439726›Full record

ReviewFuture microbiology2012

Oxidative stress resistance in Porphyromonas gingivalis.

Leroy G Henry, Rachelle M E McKenzie, Antonette Robles, Hansel M Fletcher

Open access · greenAbstract readReview
In one paragraph

Review in Future microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Gut microbes · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Virulence diversity amongJournal of oral microbiology · 2026
    Review
  8. Transcription regulator TrtA modulates oxygen stress response inApplied and environmental microbiology · 2025
    Article
  9. Article
  10. Exploring the Genetic and Functional Diversity ofInternational journal of molecular sciences · 2025
    Article
  11. CRISPRJournal of oral microbiology · 2025
    Article
  12. Article
  13. Article
  14. AmSystems · 2024
    Article
  15. Review
  16. The polymicrobial pathogenicity ofFrontiers in oral health · 2024
    Article
  17. Article
  18. Review
  19. Prevalence and Phylogenetic Analysis of Lipoprotein-GeneAntibiotics (Basel, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Leroy G HenryDivision of Microbiology & Molecular Genetics, School of Medicine, Loma Linda, CA 92350, USA.
Rachelle M E McKenzie
Antonette Robles
Hansel M Fletcher
Loma Linda University · US

Funding

Studies on virulence regulation in PorphyromonasR01DE013664 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2002 to 2011
$3.3M
Mechanisms for adaptation to oxidative stress in Porphyromonas gingivalisR01DE019730 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2009 to 2013
$2.0M
ECF sigma factors in adaptation and virulence of Porphyromonas gingivalisR01DE022508 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2012 to 2016
$1.8M
Studies on the virulence regulation in PorphyromonasR56DE013664 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2014 to 2014
$291k
NIDCR NIH HHS DE019730NIDCR NIH HHS DE13664NIDCR NIH HHS R01 DE013664NIDCR NIH HHS R01 DE019730NIDCR NIH HHS R01 DE022508NIDCR NIH HHS R56 DE013664
6 · The paper itself

Abstract

Porphyromonas gingivalis, a black-pigmented, Gram-negative anaerobe, is an important etiologic agent of periodontal disease. The harsh inflammatory condition of the periodontal pocket implies that this organism has properties that will facilitate its ability to respond and adapt to oxidative stress. Because the stress response in the pathogen is a major determinant of its virulence, a comprehensive understanding of its oxidative stress resistance strategy is vital. We discuss multiple mechanisms and systems that clearly work in synergy to defend and protect P. gingivalis against oxidative damage caused by reactive oxygen species. The involvement of multiple hypothetical proteins and/or proteins of unknown function in this process may imply other unique mechanisms and potential therapeutic targets.

Indexed as

Oxidative StressAnimalsBacterial ProteinsHumansPeriodontal DiseasesPorphyromonas gingivalisReactive Oxygen SpeciesBacterial ProteinsReactive Oxygen Species

Identifiers

PMID22439726
PMCPMC3397238
OpenAlexW1974359279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.