ArticleBMC genomics2012
Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 74 citations in OpenAlex.
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- Neo-Sex Chromosome Evolution in Treehoppers Despite Long-Term X Chromosome Conservation.Genome biology and evolution · 2024Article
- Rewinding the Ratchet: Rare Recombination Locally Rescues Neo-W Degeneration and Generates Plateaus of Sex-Chromosome Divergence.Molecular biology and evolution · 2024Article
- Article
- Comprehending the dynamism of B chromosomes in their journey towards becoming unselfish.Frontiers in cell and developmental biology · 2022Review
- A supernumerary "B-sex" chromosome drives male sex determination in the Pachón cavefish, Astyanax mexicanus.Current biology : CB · 2021Article
- Rapid divergence of the male reproductive proteins in the Drosophila dunni group and implications for postmating incompatibilities between species.G3 (Bethesda, Md.) · 2021Article
- A genomic glimpse of B chromosomes in cichlids.Genes & genomics · 2021Review
- De novo assembly, annotation and gene expression profiles of gonads of Cytorace-3, a hybrid lineage of Drosophila nasuta nasuta and D. n. albomicans.Genomics & informatics · 2021Article
- Sequence analysis inGenome research · 2020Article
- The genomes of a monogenic fly: views of primitive sex chromosomes.Scientific reports · 2020Article
- BlobToolKit - Interactive Quality Assessment of Genome Assemblies.G3 (Bethesda, Md.) · 2020Article
- Patterns of Genomic Differentiation in the Drosophila nasuta Species Complex.Molecular biology and evolution · 2020Article
- Changing sex for selfish gain: B chromosomes of Lake Malawi cichlid fish.Scientific reports · 2019Article
- Genome Size Evolution Differs BetweenG3 (Bethesda, Md.) · 2019Article
- The Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genes.Molecular biology and evolution · 2019Article
- Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects.Chromosoma · 2019Article
- Review
- Review
- Contingency in the convergent evolution of a regulatory network: Dosage compensation in Drosophila.PLoS biology · 2019Article
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Authors and funding
16 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundDrosophila albomicans is a unique model organism for studying both sex chromosome and B chromosome evolution. A pair of its autosomes comprising roughly 40% of the whole genome has fused to the ancient X and Y chromosomes only about 0.12 million years ago, thereby creating the youngest and most gene-rich neo-sex system reported to date. This species also possesses recently derived B chromosomes that show non-Mendelian inheritance and significantly influence fertility.
methodsWe sequenced male flies with B chromosomes at 124.5-fold genome coverage using next-generation sequencing. To characterize neo-Y specific changes and B chromosome sequences, we also sequenced inbred female flies derived from the same strain but without B's at 28.5-fold.
resultsWe assembled a female genome and placed 53% of the sequence and 85% of the annotated proteins into specific chromosomes, by comparison with the 12 Drosophila genomes. Despite its very recent origin, the non-recombining neo-Y chromosome shows various signs of degeneration, including a significant enrichment of non-functional genes compared to the neo-X, and an excess of tandem duplications relative to other chromosomes. We also characterized a B-chromosome linked scaffold that contains an actively transcribed unit and shows sequence similarity to the subcentromeric regions of both the ancient X and the neo-X chromosome.
conclusionsOur results provide novel insights into the very early stages of sex chromosome evolution and B chromosome origination, and suggest an unprecedented connection between the births of these two systems in D. albomicans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.