ArticleChinese medicine2012
NMR evaluation of total statin content and HMG-CoA reductase inhibition in red yeast rice (Monascus spp.) food supplements.
Article in Chinese medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Red yeast rice with monacolin K for the improvement of hyperlipidemia: A narrative review.World journal of clinical cases · 2025Review
- Scientific Opinion on additional scientific data related to the safety of monacolins from red yeast rice submitted pursuant to Article 8(4) of Regulation (EC) No 1925/2006.EFSA journal. European Food Safety Authority · 2025Article
- Review
- Red Yeast Rice or Lovastatin? A Comparative Evaluation of Safety and Efficacy Through a Multifaceted Approach.Phytotherapy research : PTR · 2025Article
- The Questionable Quality Profile of Food Supplements: The Case of Red Yeast Rice Marketed Products.Foods (Basel, Switzerland) · 2023Article
- DRDB: A Machine Learning Platform to Predict Chemical-Protein Interactions towards Diabetic Retinopathy.Oxidative medicine and cellular longevity · 2022Article
- Utilization of agro-industrial by-products in Monascus fermentation: a review.Bioresources and bioprocessing · 2021Review
- Fungal Pigments: Potential Coloring Compounds for Wide Ranging Applications in Textile Dyeing.Journal of fungi (Basel, Switzerland) · 2020Review
- Comparative Chemical Profiling and Monacolins Quantification in Red Yeast Rice Dietary Supplements byMolecules (Basel, Switzerland) · 2020Article
- Lupin Peptide T9 (GQEQSHQDEGVIVR) Modulates the Mutant PCSK9Nutrients · 2019Article
- Optimization of Ultrasonic-Assisted Extraction of Total Phenolics fromMolecules (Basel, Switzerland) · 2019Article
- Quality and Authenticity Control of Functional Red Yeast Rice-A Review.Molecules (Basel, Switzerland) · 2019Review
- Nature and nurture: confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments.Natural product reports · 2019Review
- Functional food red yeast rice (RYR) for metabolic syndrome amelioration: a review on pros and cons.World journal of microbiology & biotechnology · 2016Review
- Optimization, validation and application of an assay for the activity of HMG-CoA reductaseJournal of pharmaceutical analysis · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRed yeast rice (i.e., rice fermented with Monascus spp.), as a food supplement, is claimed to be blood cholesterol-lowering. The red yeast rice constituent monacolin K, also known as lovastatin, is an inhibitor of the hydroxymethylglutaryl-CoA (HMG-CoA) reductase. This article aims to develop a sensitive nuclear magnetic resonance (NMR) method to determine the total statin content of red yeast rice products.
methodsThe total statin content was determined by a 400 MHz 1H NMR spectroscopic method, based on the integration of the multiplet at δ 5.37-5.32 ppm of a hydrogen at the hexahydronaphthalene moiety in comparison to an external calibration with lovastatin. The activity of HMG-CoA reductase was measured by a commercial spectrophotometric assay kit.
resultsThe NMR detection limit for total statins was 6 mg/L (equivalent to 0.3 mg/capsule, if two capsules are dissolved in 50 mL ethanol). The relative standard deviations were consistently lower than 11%. The total statin concentrations of five red yeast rice supplements were between 1.5 and 25.2 mg per specified daily dose. A dose-dependent inhibition of the HMG-CoA reductase enzyme activity by the red yeast rice products was demonstrated.
conclusionA simple and direct NMR assay was developed to determine the total statin content in red yeast rice. The assay can be applied for the determination of statin content for the regulatory control of red yeast rice products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.