Evidence map›Paper›PMID 22439622›Full record

ArticleJournal of natural products2012

Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp.

Zhenjian Lin, Malem Flores, Imelda Forteza, Niel M Henriksen, Gisela P Concepcion, Gary Rosenberg, Margo G Haygood, Baldomero M Olivera, Alan R Light, Thomas E Cheatham and 1 more

Abstract read
In one paragraph

Article in Journal of natural products, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  3. Review
  4. Angucycline-like Aromatic Polyketide from a NovelAntibiotics (Basel, Switzerland) · 2020
    Article
  5. Article
  6. Review
  7. Review
  8. Natural products chemistry: The emerging trends and prospective goals.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhenjian LinCollege of Pharmacy, Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA.
Malem Flores
Imelda Forteza
Niel M Henriksen
Gisela P Concepcion
Gary Rosenberg
Margo G Haygood
Baldomero M Olivera
Alan R Light
Thomas E Cheatham
Eric W Schmidt

Funding

Diverse Drug Lead Compounds from Bacterial Symbionts in Philippine MollusksU19TW008163 · FIC · UNIVERSITY OF UTAH · PI HAYGOOD, MARGO GENEVIEVE · 2014 to 2018
$5.2M
Diverse drug lead compounds from bacterial symbionts in tropical marine mollusksU01TW008163 · FIC · OREGON HEALTH & SCIENCE UNIVERSITY · PI HAYGOOD, MARGO GENEVIEVE · 2008 to 2013
$4.3M
FIC NIH HHS U01 TW008163FIC NIH HHS U01TW008163FIC NIH HHS U19 TW008163
6 · The paper itself

Abstract

Two new compounds, the peptide-polyketide glycoside totopotensamide A (1) and its aglycone totopotensamide B (2), were isolated from a Streptomyces sp. cultivated from the gastropod mollusk Lienardia totopotens collected in the Philippines. The compounds contain a previously undescribed polyketide component, a novel 2,3-diaminobutyric acid-containing macrolactam, and a new amino acid, 4-chloro-5,7-dihydroxy-6-methylphenylglycine. The application of Marfey's method to phenylglycine derivatives was explored using quantum mechanical calculations and NMR.

Indexed as

AnimalsGlycosidesMolecular StructureMolluscaNuclear Magnetic Resonance, BiomolecularPeptides, CyclicPhilippinesPolyketidesStreptomycesGlycosidesPeptides, CyclicPolyketidestotopotensamide Atotopotensamide B

Identifiers

PMID22439622
PMCPMC3338888

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.