Trial reportRadiation oncology (London, England)2012
Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas.
Trial report in Radiation oncology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A meta-analysis comparing efficacy and safety between proton beam therapy versus carbon ion radiotherapy.Cancer medicine · 2024Pooled it
- Review
- Carbon-ions, protons or photons for head and neck cancer radiotherapy-an in silico planning study.Physical and engineering sciences in medicine · 2026Article
- Article
- Adjuvant proton beam therapy in patients with grade 2 meningiomas.Surgical neurology international · 2024Article
- Particle beam radiotherapy in the treatment of WHO grade 2 and 3 meningiomas: an early experience from Shanghai Proton and Heavy Ion Center.Journal of neuro-oncology · 2023Article
- Rotating Gantries Provide Individualized Beam Arrangements for Charged Particle Therapy.Cancers · 2023Article
- Long-term outcomes of fractionated proton beam therapy for benign or radiographic intracranial meningioma.Journal of neuro-oncology · 2023Article
- Radiation Therapy for Chordomas and Chondrosarcomas of the Skull Base: Evaluation of the Effectiveness of Treatment Methods (Review).Sovremennye tekhnologii v meditsine · 2023Review
- Article
- Fixed Beamline Optimization for Intensity Modulated Carbon-Ion Therapy.IEEE transactions on radiation and plasma medical sciences · 2022Article
- Long-term outcomes of patients with unresectable benign meningioma treated with proton beam therapy.Journal of radiation research · 2021Article
- Particle therapy in the future of precision therapy.The British journal of radiology · 2020Review
- Review of Atypical and Anaplastic Meningiomas: Classification, Molecular Biology, and Management.Frontiers in oncology · 2020Review
- Proton Therapy for Intracranial Meningioma for the Treatment of Primary/Recurrent Disease Including Re-Irradiation.Frontiers in oncology · 2020Review
- The preliminary results of proton and carbon ion therapy for chordoma and chondrosarcoma of the skull base and cervical spine.Radiation oncology (London, England) · 2019Article
- Clinical outcome after particle therapy for meningiomas of the skull base: toxicity and local control in patients treated with active rasterscanning.Radiation oncology (London, England) · 2018Article
- Protons, Photons, and the Prostate - Is There Emerging Evidence in the Ongoing Discussion on Particle Therapy for the Treatment of Prostate Cancer?Frontiers in oncology · 2016Review
- Bringing the heavy: carbon ion therapy in the radiobiological and clinical context.Radiation oncology (London, England) · 2014Review
- Treatment Planning Comparison of Gantry-based and Fixed Beams for the Treatment of Liver Tumors With Carbon Ion Therapy.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo examine the potential improvement in treatment planning for patients with skull base meningioma using IMRT compared to carbon ion or proton beams with and without a gantry.
methodsFive patients originally treated with photon IMRT were selected for the study. Ion beams were chosen using a horizontal beam or an ion gantry. Intensity controlled raster scanning and the intensity modulated particle therapy mode were used for plan optimization. The evaluation included analysis of dose-volume histograms of the target volumes and organs at risk.
resultsIn comparison with carbon and proton beams only with horizontal beams, carbon ion treatment plans could spare the OARs more and concentrated on the target volumes more than proton and photon IMRT treatment plans. Using only a horizontal fixed beam, satisfactory plans could be achieved for skull base tumors.
conclusionThe results of the case studies showed that using IMPT has the potential to overcome the lack of a gantry for skull base tumors. Carbon ion plans offered slightly better dose distributions than proton plans, but the differences were not clinically significant with established dose prescription concepts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.