ArticleSurgical neurology international2012
Duplication of the pituitary gland associated with multiple blastogenesis defects: Duplication of the pituitary gland (DPG)-plus syndrome. Case report and review of literature.
Article in Surgical neurology international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Congenital/primary clival meningocele: A systematic review and surgical approach based on a new proposed classification.Neurosurgical review · 2026Pooled it
- New patients with duplication of the pituitary gland-plus syndrome, including aJournal of medical genetics · 2025Review
- Pituitary Gland Duplication Syndrome: An International Imaging Analysis.AJNR. American journal of neuroradiology · 2025Article
- Central precocious puberty associated with duplicated pituitary: a case report and literature review.Frontiers in endocrinology · 2025Review
- Brain malformations in diprosopia observed in clinical cases, museum specimens and artistic representations.Orphanet journal of rare diseases · 2023Article
- Duplication of the Pituitary Gland: CT, MRI and DTI Findings and Updated Review of the Literature.Brain sciences · 2022Article
- A persistent craniopharyngeal canal with recurrent bacterial meningitis: case report and literature review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Review
- Duplication of the Pituitary Gland (DPG)-Plus Syndrome Associated With Midline Anomalies and Precocious Puberty: A Case Report and Review of the Literature.Frontiers in endocrinology · 2021Review
- Duplication of the odontoid process with other congenital defects of the craniocervical Junction: case report and review of the literature.Anatomy & cell biology · 2020Article
- Endoscopic Resection of Skull Base Teratoma in Klippel-Feil Syndrome through Use of Combined Ultrasonic and Bipolar Diathermy Platforms.Case reports in otolaryngology · 2017Article
- DPG-plus syndrome: new report of a rare entity.BMJ case reports · 2015Article
- CT and MRI of congenital nasal lesions in syndromic conditions.Pediatric radiology · 2015Review
- Magnetic resonance imaging of sellar and juxtasellar abnormalities in the paediatric population: an imaging review.Insights into imaging · 2015Article
- Diagnostic imaging features of congenital nose and nasal cavity lesions.Clinical neuroradiology · 2015Review
- Craniopharyngeal canal and its spectrum of pathology.AJNR. American journal of neuroradiology · 2014Article
- UNIQUE PRESENTATION OF DUPLICATION OF THE PITUITARY GLAND-PLUS SYNDROME.AACE clinical case reportsArticle
- Duplication of the pituitary gland - plus syndrome.The Indian journal of radiology & imagingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuplication of the pituitary gland (DPG) is a rare craniofacial developmental anomaly occurring during blastogenesis with postulated etiology such as incomplete twinning, teratogens, median cleft face syndrome or splitting of the notochord. The complex craniocaudal spectrum of blastogenesis defects associated with DPG is examined with an illustrative case. CASE DESCRIPTION: We report for the first time in the medical literature some unique associations with DPG, such as a clival encephalocele, third cerebral peduncle, duplicate odontoid process and a double tongue with independent volitional control. This patient also has the previously reported common associations such as duplicated sella, cleft palate, hypertelorism, callosal agenesis, hypothalamic enlargement, nasopharyngeal teratoma, fenestrated basilar artery and supernumerary teeth. This study also reviews 37 cases of DPG identified through MEDLINE literature search from 1880 to 2011. It provides a detailed analysis of the current case through physical examination and imaging.
conclusionThe authors propose that the developmental deformities associated with duplication of pituitary gland (DPG) occur as part of a developmental continuum, not as chance associations. Considering the fact that DPG is uniquely and certainly present throughout the spectrum of these blastogenesis defects, we suggest the term DPG-plus syndrome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.