ArticlePloS one2012
Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Restoration of Attention by Rest in a Multitasking World: Theory, Methodology, and Empirical Evidence.Frontiers in psychology · 2022Pooled it
- Effects of tolcapone and bromocriptine on cognitive stability and flexibility.Psychopharmacology · 2018Trial
- Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study.Neuroimage. Reports · 2026Article
- Perspectives on ionizing radiation and Parkinson's disease.NPJ Parkinson's disease · 2026Review
- VNTR Polymorphisms in theBioengineering (Basel, Switzerland) · 2025Article
- Structural neural correlates of mental fatigue and reward-induced improvement in performance.Biologia futura · 2024Article
- Will the real resource theory please stand up! Vigilance is a renewable resource and should be modeled as such.Experimental brain research · 2023Article
- Foreword: Festschrift in honor of David Dinges, scientist and mentor extraordinaire.Sleep advances : a journal of the Sleep Research Society · 2023Article
- Slowed reaction times in cognitive fatigue are not attributable to declines in motor preparation.Experimental brain research · 2022Article
- Role of Catechol-O-methyltransferase Val158Met Polymorphism on Transcranial Direct Current Stimulation in Swallowing.Journal of personalized medicine · 2022Article
- The Link Between Energy-Related Sensations and Metabolism: Implications for Treating Fatigue.Frontiers in psychology · 2022Review
- Effects of Caffeine Intake on Cognitive Performance Related to Total Sleep Deprivation and Time on Task: A Randomized Cross-Over Double-Blind Study.Nature and science of sleep · 2022Article
- Cognitive Fatigue Effects on Physical Performance: The Role of Interoception.Sports medicine (Auckland, N.Z.) · 2020Article
- The Effect of Mental Fatigue on Neuromuscular Function is Similar in Young and Older Women.Brain sciences · 2020Article
- Fronto-Parietal Subnetworks Flexibility Compensates For Cognitive Decline Due To Mental Fatigue.Human brain mapping · 2018Article
- Perceived fatigue and energy are independent unipolar states: Supporting evidence.Medical hypotheses · 2018Article
- Dopaminergic Genetic Variants and Voluntary Externally Paced Exercise Behavior.Medicine and science in sports and exercise · 2018Article
- Positive Effects of Mindfulness-Based Training on Energy Maintenance and the EEG Correlates of Sustained Attention in a Cohort of Nurses.Frontiers in human neuroscience · 2018Article
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Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolonged demands on the attention system can cause a decay in performance over time known as the time-on-task effect. The inter-subject differences in the rate of this decline are large, and recent efforts have been made to understand the biological bases of these individual differences. In this study, we investigate the genetic correlates of the time-on-task effect, as well as its accompanying changes in subjective fatigue and mood. N = 332 subjects performed a 20-minute test of sustained attention (the Psychomotor Vigilance Test) and rated their subjective states before and after the test. We observed substantial time-on-task effects on average, and large inter-individual differences in the rate of these declines. The 10-repeat allele of the variable number of tandem repeats marker (VNTR) in the dopamine transporter gene and the Met allele of the catechol-o-methyl transferase (COMT) Val158Met polymorphism were associated with greater vulnerability to time-on-task. Separately, the exon III DRD4 48 bp VNTR of the dopamine receptor gene DRD4 was associated with subjective decreases in energy. No polymorphisms were associated with task-induced changes in mood. We posit that the dopamine transporter and COMT genes exert their effects by increasing dopaminergic tone, which may induce long-term changes in the prefrontal cortex, an important mediator of sustained attention. Thus, these alleles may affect performance particularly when sustained dopamine release is necessary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.