ArticlePloS one2012
Predictors of poor CD4 and weight recovery in HIV-infected children initiating ART in South Africa.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Leaf concentrate compared with skimmed milk as nutritional supplementation for HIV-infected children: a randomized controlled trial in Burundi.Public health nutrition · 2016Trial
- Virologic, immunologic and clinical response of infants to antiretroviral therapy in Kampala, Uganda.BMC pediatrics · 2013Trial
- Population-Specific Predictors of Immunologic Reconstitution Following Initiation of Combined Antiretroviral Therapy in Children: A Retrospective Observational Study from a 15-Year Cohort of HIV-Positive Children and Adolescents in Eritrea.HIV/AIDS (Auckland, N.Z.) · 2024Article
- Article
- Weight gain in children from birth to 10 years on antiretroviral treatment.Southern African journal of HIV medicine · 2022Article
- Predictors of CD4 count changes over time among children who initiated highly active antiretroviral therapy in Ethiopia.Tropical medicine and health · 2020Article
- Impact of antiretroviral treatment on height evolution of HIV infected children.BMC pediatrics · 2019Article
- Clinical, Immunological and Virological Responses of Zidovudine-Lamivudine-NevirapineThe open medical informatics journal · 2018Article
- Higher retention and viral suppression with adolescent-focused HIV clinic in South Africa.PloS one · 2017Article
- Predictors of Infant Age at Enrollment in Early Infant Diagnosis Services in Kenya.AIDS and behavior · 2016Article
- Effect of Age at Antiretroviral Therapy Initiation on Catch-up Growth Within the First 24 Months Among HIV-infected Children in the IeDEA West African Pediatric Cohort.The Pediatric infectious disease journal · 2015Observational
- The effect of tuberculosis treatment on virologic and immunologic response to combination antiretroviral therapy among South African children.Journal of acquired immune deficiency syndromes (1999) · 2014Article
- Temporal trends in the characteristics of children at antiretroviral therapy initiation in southern Africa: the IeDEA-SA Collaboration.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo identify baseline demographic and clinical risk factors associated with poor CD4 and weight response after initiation of antiretroviral therapy (ART) in a cohort of human immunodeficiency virus (HIV)-infected children in KwaZulu-Natal, South Africa.
methodsWe performed a retrospective cohort study of 674 children initiating antiretroviral therapy at McCord and St. Mary's hospitals in KwaZulu-Natal, South Africa, from August 2003 to December 2008. We extracted data from paper charts and electronic medical records to assess risk factors associated with CD4 and weight response using logistic regression.
resultsFrom the initial cohort of 901 children <10 years old initiating ART between August 2003 and December 2008, we analyzed 674 children with complete baseline data. Viral suppression rates (<400 copies/ml) were 84% after six months of therapy and 88% after 12 months of therapy. Seventy-three percent of children achieved CD4 recovery after six months and 89% after 12 months. Weight-for-age Z-score (WAZ) improvements were seen in 58% of children after six months of ART and 64% after 12 months. After six months of ART, lower baseline hemoglobin (p = 0.037), presence of chronic diarrhea (p = 0.007), and virologic failure (p = 0.046) were all associated with poor CD4 recovery by multivariate logistic regression. After 12 months of ART, poor CD4 recovery was associated with higher baseline CD4% (p = 0.005), chronic diarrhea (p = 0.02), and virologic failure (p<0.001). Age less than 3 years at ART initiation (p = 0.0003), higher baseline CD4% (p<0.001), and higher baseline WAZ (p<0.001) were all associated with poor WAZ improvements after 6 months by multivariate logistic regression.
conclusionThe presence of chronic diarrhea at baseline, independent of nutritional status and viral response, predicts poor CD4 recovery. Age at initiation of ART is an important factor in early WAZ response to ART, while viral suppression strongly predicts CD4 recovery but not WAZ improvement.
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