ArticlePloS one2012
Beta defensin-2 is reduced in central but not in distal airways of smoker COPD patients.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 81 citations in OpenAlex.
- Lung antimicrobial proteins and peptides: from host defense to therapeutic strategies.Physiological reviews · 2024Review
- Effects of condensates from volcanic fumaroles and cigarette smoke extracts on airway epithelial cells.Human cell · 2023Article
- Mechanisms and regulation of defensins in host defense.Signal transduction and targeted therapy · 2023Review
- Increased expression of miR146a dysregulates TLR2-induced HBD2 in airway epithelial cells from patients with COPD.ERJ open research · 2023Article
- Advances in Antimicrobial Peptide Discovery via Machine Learning and Delivery via Nanotechnology.Microorganisms · 2023Review
- Low human beta-defensin-2 levels in the sputum of COPD patients are associated with the risk of exacerbations.BMC pulmonary medicine · 2023Article
- Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease.Frontiers in immunology · 2023Article
- Effects of Fluticasone Propionate onmSphere · 2022Article
- High Mobility Group Box 1: Biological Functions and Relevance in Oxidative Stress Related Chronic Diseases.Cells · 2022Review
- Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease.Frontiers in immunology · 2022Review
- Variability of blood eosinophil count and prognosis of COPD exacerbations.Annals of medicine · 2021Observational
- Cigarette smoke and electronic cigarettes differentially activate bronchial epithelial cells.Respiratory research · 2020Article
- Impact of Hyponatremia on COPD Exacerbation Prognosis.Journal of clinical medicine · 2020Article
- Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmonary disease.Science translational medicine · 2019Article
- Infection resisters: targets of new research for uncovering natural protective immunity againstF1000Research · 2019Review
- SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells.Journal of cellular and molecular medicine · 2018Article
- Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance.Respiratory research · 2018Article
- Neuropeptides SP and CGRP Diminish theMediators of inflammation · 2018Article
- One-year and long-term mortality in patients hospitalized for chronic obstructive pulmonary disease.Journal of thoracic disease · 2017Article
- Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.Journal of innate immunity · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAltered pulmonary defenses in chronic obstructive pulmonary disease (COPD) may promote distal airways bacterial colonization. The expression/activation of Toll Like receptors (TLR) and beta 2 defensin (HBD2) release by epithelial cells crucially affect pulmonary defence mechanisms.
methodsThe epithelial expression of TLR4 and of HBD2 was assessed in surgical specimens from current smokers COPD (s-COPD; n = 17), ex-smokers COPD (ex-s-COPD; n = 8), smokers without COPD (S; n = 12), and from non-smoker non-COPD subjects (C; n = 13).
resultsIn distal airways, s-COPD highly expressed TLR4 and HBD2. In central airways, S and s-COPD showed increased TLR4 expression. Lower HBD2 expression was observed in central airways of s-COPD when compared to S and to ex-s-COPD. s-COPD had a reduced HBD2 gene expression as demonstrated by real-time PCR on micro-dissected bronchial epithelial cells. Furthermore, HBD2 expression positively correlated with FEV1/FVC ratio and inversely correlated with the cigarette smoke exposure. In a bronchial epithelial cell line (16 HBE) IL-1β significantly induced the HBD2 mRNA expression and cigarette smoke extracts significantly counteracted this IL-1 mediated effect reducing both the activation of NFkB pathway and the interaction between NFkB and HBD2 promoter.
conclusionsThis study provides new insights on the possible mechanisms involved in the alteration of innate immunity mechanisms in COPD.
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