ArticlePloS one2012
Quantitative proteome profiling of C. burnetii under tetracycline stress conditions.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Entomopathogenic fungus treatment changes the gut bacterial diversity of Rhipicephalus microplus ticks.Parasites & vectors · 2023Article
- Pathogenic and Endosymbiotic Bacteria and Their Associated Antibiotic Resistance Biomarkers inPathogens (Basel, Switzerland) · 2022Article
- Relevance of peroxiredoxins in pathogenic microorganisms.Applied microbiology and biotechnology · 2021Review
- Proteomic and Transcriptomic Analyses Indicate Reduced Biofilm-Forming Abilities in Cefiderocol-ResistantFrontiers in microbiology · 2021Article
- Genotyping of Coxiella burnetii in sheep and goat abortion samples.BMC microbiology · 2018Article
- Stress response of Escherichia coli to essential oil components - insights on low-molecular-weight proteins from MALDI-TOF.Scientific reports · 2018Article
- Article
- Sharpening Host Defenses during Infection: Proteases Cut to the Chase.Molecular & cellular proteomics : MCP · 2017Review
- Chronic exposure of river sediments to environmentally relevant levels of tetracycline affects bacterial communities but not denitrification rates.Ecotoxicology (London, England) · 2013Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recommended antibiotic regimen against Coxiella burnetii, the etiological agent of Q fever, is based on a semi-synthetic, second-generation tetracycline, doxycycline. Here, we report on the comparison of the proteomes of a C. burnetii reference strain either cultured under control conditions or under tetracycline stress conditions. Using the MS-driven combined fractional diagonal chromatography proteomics technique, out of the 531 proteins identified, 5 and 19 proteins were found significantly up- and down-regulated respectively, under tetracycline stress. Although the predicted cellular functions of these regulated proteins did not point to known tetracycline resistance mechanisms, our data clearly reveal the plasticity of the proteome of C. burnetii to battle tetracycline stress. Finally, we raise several plausible hypotheses that could further lead to more focused experiments on studying tetracycline resistance in C. burnetii and thus reduced treatment failures of Q fever.
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