ArticlePLoS genetics2012
ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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Who cites it
93 citing papers in PubMed.
- Mating imperatives drive plasticity of the daily temporal niche in fruit flies.Nature ecology & evolution · 2026Article
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- Visual recognition of the anteroposterior female body axis drives spatial elements of male courtship in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Article
- Strain variation identifies a neural substrate for behavioral evolution in Drosophila.Current biology : CB · 2026Article
- Multimodal social context modulates larval behavior inScience advances · 2026Article
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- A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025Article
- Strain variation identifies a neural substrate for behavioral evolution inbioRxiv : the preprint server for biology · 2025Article
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Evolutionary Genomics of Gene Families: A Case Study of Insect Gustatory Receptors.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Function and evolution of Ir52 receptors in mate detection in Drosophila.Current biology : CB · 2024Article
- Article
- Male cuticular pheromones stimulate removal of the mating plug and promote re-mating through pC1 neurons ineLife · 2024Article
- A neural pathway for social modulation of spontaneous locomotor activity (SoMo-SLA) inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Larval microbiota primes the Drosophila adult gustatory response.Nature communications · 2024Article
- Identification of candidate genes associated with host-seeking behavior in the parasitoid wasp Diachasmimorpha longicaudata.BMC genomics · 2024Article
- A modular circuit architecture coordinates the diversification of courtship strategies inbioRxiv : the preprint server for biology · 2023Article
- Intense light unleashes male-male courtship behaviour in wild-typeOpen biology · 2023Article
- A single-cell atlas of the sexually dimorphic Drosophila foreleg and its sensory organs during development.PLoS biology · 2023Article
33 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
Insects utilize diverse families of ion channels to respond to environmental cues and control mating, feeding, and the response to threats. Although degenerin/epithelial sodium channels (DEG/ENaC) represent one of the largest families of ion channels in Drosophila melanogaster, the physiological functions of these proteins are still poorly understood. We found that the DEG/ENaC channel ppk23 is expressed in a subpopulation of sexually dimorphic gustatory-like chemosensory bristles that are distinct from those expressing feeding-related gustatory receptors. Disrupting ppk23 or inhibiting activity of ppk23-expressing neurons did not alter gustatory responses. Instead, blocking ppk23-positive neurons or mutating the ppk23 gene delayed the initiation and reduced the intensity of male courtship. Furthermore, mutations in ppk23 altered the behavioral response of males to the female-specific aphrodisiac pheromone 7(Z), 11(Z)-Heptacosadiene. Together, these data indicate that ppk23 and the cells expressing it play an important role in the peripheral sensory system that determines sexual behavior in Drosophila.
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