ArticlePLoS genetics2012
Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Genetic Variants inDiabetes · 2018Trial
- Phenotypic and genomic frameworks for precision pharmacotherapy in obesity: a narrative review.Frontiers in medicine · 2026Review
- Neurobeachin (NBEA) is a novel gene associated with GLP-1 receptor agonist associated weight loss.Diabetes, obesity & metabolism · 2025Article
- Neurobeachin regulates hematopoietic progenitor differentiation and survival by modulating Notch activity.Blood advances · 2024Article
- Correlation of mutated gene and signalling pathways in ASD.IBRO neuroscience reports · 2023Review
- Article
- Synapse-associated protein 102 - a highly mobile MAGUK predominate in early synaptogenesis.Frontiers in molecular neuroscience · 2023Review
- Article
- Neurobeachin, a promising target for use in the treatment of alcohol use disorder.Addiction biology · 2022Article
- Signature selection analysis reveals candidate genes associated with production traits in Iranian sheep breeds.BMC veterinary research · 2021Article
- Neural Basis of Dysregulation of Palatability-Driven Appetite in Autism.Current nutrition reports · 2021Review
- Identification of Major Loci and Candidate Genes for Meat Production-Related Traits in Broilers.Frontiers in genetics · 2021Article
- Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice.Nature communications · 2020Article
- Integration of transcriptomic data in a genome-scale metabolic model to investigate the link between obesity and breast cancer.BMC bioinformatics · 2019Article
- Article
- Integrative analysis of methylomic and transcriptomic data in fetal sheep muscle tissues in response to maternal diet during pregnancy.BMC genomics · 2018Article
- The BEACH Protein LRBA Promotes the Localization of the Heterotrimeric G-protein GScientific reports · 2017Article
- Genetic and Genomic Response to Selection for Food Consumption in Drosophila melanogaster.Behavior genetics · 2017Article
- Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.Nature communications · 2016Article
- The BEACH Domain Protein SPIRRIG Is Essential for Arabidopsis Salt Stress Tolerance and Functions as a Regulator of Transcript Stabilization and Localization.PLoS biology · 2015Article
Corrections and comments
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Authors and funding
25 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal death. Here, we report that heterozygous KO mice haploinsufficient for Nbea have higher body weight due to increased adipose tissue mass. In several feeding paradigms, heterozygous KO mice consumed more food than wild-type (WT) controls, and this consumption was primarily driven by calories rather than palatability. Expression analysis of feeding-related genes in the hypothalamus and brainstem with real-time PCR showed differential expression of a subset of neuropeptide or neuropeptide receptor mRNAs between WT and Nbea+/- mice in the sated state and in response to food deprivation, but not to feeding reward. In humans, we identified two intronic NBEA single-nucleotide polymorphisms (SNPs) that are significantly associated with body-mass index (BMI) in adult and juvenile cohorts. Overall, data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits. Our study emphasizes the importance of neural mechanisms in body weight control and points out NBEA as a potential risk gene in human obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.