ArticlePLoS computational biology2012
Cell shape dynamics: from waves to migration.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Inferring cell division from cell shape.The Plant cell · 2026Article
- Morphomechanically-Informed Spatial Curvature Sequencing in Prostate Cancer.bioRxiv : the preprint server for biology · 2026Article
- Fourier-Based Non-Rigid Slice-to-Volume Registration of Segmented Petrographic LM and CT Scans of Concrete Specimens.Materials (Basel, Switzerland) · 2026Article
- Biregionally differentiated growth generates sharp apex and concave joints in leaves.The Plant journal : for cell and molecular biology · 2025Article
- Emergence of multiple collective motility modes in a physical model of cell chains.NPJ systems biology and applications · 2025Article
- Facile Physicochemical Reprogramming of PEG-Dithiolane Microgels.Advanced healthcare materials · 2024Article
- Nuclear curvature determines Yes-associated protein localization and differentiation of mesenchymal stem cells.Biophysical journal · 2024Article
- Drosophila TMEM63 and mouse TMEM63A are lysosomal mechanosensory ion channels.Nature cell biology · 2024Article
- Three-component contour dynamics model to simulate and analyze amoeboid cell motility in two dimensions.PloS one · 2024Article
- A Hands-on Guide to AmoePy - a Python-Based Software Package to Analyze Cell Migration Data.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles.Nature communications · 2023Article
- Article
- Polarized branched Actin modulates cortical mechanics to produce unequal-size daughters during asymmetric division.Nature cell biology · 2023Article
- Random walk and cell morphology dynamics inFrontiers in cell and developmental biology · 2023Article
- ATP levels influence cell movement during the mound phase in Dictyostelium discoideum as revealed by ATP visualization and simulation.FEBS open bio · 2022Article
- T cell morphodynamics reveal periodic shape oscillations in three-dimensional migration.Journal of the Royal Society, Interface · 2022Article
- Cortical softening elicits zygotic contractility during mouse preimplantation development.PLoS biology · 2022Article
- Genetic characterization of carrot root shape and size using genome-wide association analysis and genomic-estimated breeding values.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Actin Dynamics as a Multiscale Integrator of Cellular Guidance Cues.Frontiers in cell and developmental biology · 2022Article
- Spontaneous transitions between amoeboid and keratocyte-like modes of migration.Frontiers in cell and developmental biology · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
We observe and quantify wave-like characteristics of amoeboid migration. Using the amoeba Dictyostelium discoideum, a model system for the study of chemotaxis, we demonstrate that cell shape changes in a wave-like manner. Cells have regions of high boundary curvature that propagate from the leading edge toward the back, usually along alternating sides of the cell. Curvature waves are easily seen in cells that do not adhere to a surface, such as cells that are electrostatically repelled from surfaces or cells that extend over the edge of micro-fabricated cliffs. Without surface contact, curvature waves travel from the leading edge to the back of a cell at -35 µm/min. Non-adherent myosin II null cells do not exhibit these curvature waves. At the leading edge of adherent cells, curvature waves are associated with protrusive activity. Like regions of high curvature, protrusive activity travels along the boundary in a wave-like manner. Upon contact with a surface, the protrusions stop moving relative to the surface, and the boundary shape thus reflects the history of protrusive motion. The wave-like character of protrusions provides a plausible mechanism for the zig-zagging of pseudopods and for the ability of cells both to swim in viscous fluids and to navigate complex three dimensional topography.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.