ArticleExperimental neurobiology2012
Repeated Short-term (2h×14d) Emotional Stress Induces Lasting Depression-like Behavior in Mice.
Article in Experimental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Long-term effects of chronic stress models in adult mice.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Mice can recognise water depths and will avoid entering deep water.Translational neuroscience · 2022Article
- A novel mouse model of postpartum depression using emotional stress as evaluated by nesting behavior.Scientific reports · 2021Article
- Pharmacological Screening ofACS omega · 2020Article
- The impact of handling technique and handling frequency on laboratory mouse welfare is sex-specific.Scientific reports · 2020Article
- Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3β Signaling in Mice.International journal of molecular sciences · 2018Article
- Physical Exercise Counteracts Stress-induced Upregulation of Melanin-concentrating Hormone in the Brain and Stress-induced Persisting Anxiety-like Behaviors.Experimental neurobiology · 2016Article
- Chronic Antidepressant Treatment in Normal Mice Induces Anxiety and Impairs Stress-coping Ability.Experimental neurobiology · 2015Article
- Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- 1-Methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous Neuroprotectant and MAO inhibitor with antidepressant-like properties in the rat.Neurotoxicity research · 2014Article
- Anti-Depressant Like Effect of Methyl Gallate Isolated from Acer barbinerve in Mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Ketamine elicits sustained antidepressant-like activity via a serotonin-dependent mechanism.Psychopharmacology · 2013Article
- NADPH oxidase mediates depressive behavior induced by chronic stress in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic behavioral stress is a risk factor for depression. To understand chronic stress effects and the mechanism underlying stress-induced emotional changes, various animals model have been developed. We recently reported that mice treated with restraints for 2 h daily for 14 consecutive days (2h-14d or 2h×14d) show lasting depression-like behavior. Restraint provokes emotional stress in the body, but the nature of stress induced by restraints is presumably more complex than emotional stress. So a question remains unsolved whether a similar procedure with "emotional" stress is sufficient to cause depression-like behavior. To address this, we examined whether "emotional" constraints in mice treated for 2h×14d by enforcing them to individually stand on a small stepping platform placed in a water bucket with a quarter full of water, and the stress evoked by this procedure was termed "water-bucket stress". The water-bucket stress activated the hypothalamus-pituitary-adrenal gland (HPA) system in a manner similar to restraint as evidenced by elevation of serum glucocorticoids. After the 2h×14d water-bucket stress, mice showed behavioral changes that were attributed to depression-like behavior, which was stably detected >3 weeks after last water-bucket stress endorsement. Administration of the anti-depressant, imipramine, for 20 days from time after the last emotional constraint completely reversed the stress-induced depression-like behavior. These results suggest that emotional stress evokes for 2h×14d in mice stably induces depression-like behavior in mice, as does the 2h×14d restraint.
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