ArticlePharmacognosy magazine2012
Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats.
Article in Pharmacognosy magazine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 63 citations in OpenAlex.
- Soluble Dietary Fibers as Antihyperlipidemic Agents: A Comprehensive Review to Maximize Their Health Benefits.ACS omega · 2023Review
- Dietary Fiber: An Opportunity for a Global Control of Hyperlipidemia.Oxidative medicine and cellular longevity · 2021Review
- Anti-diabetic effects of the soluble dietary fiber from tartary buckwheat bran in diabetic mice and their potential mechanisms.Food & nutrition research · 2021Article
- Insight in the Recent Application of Polyphenols From Biomass.Frontiers in bioengineering and biotechnology · 2021Review
- The Antioxidant Activities ofAntioxidants (Basel, Switzerland) · 2020Article
- Hypolipidaemic Effects of High Resistant Starch Sago and Red Bean Flour- based Analog Rice on Diabetic Rats.Materia socio-medica · 2018Article
- Antihyperglycemic and Antihyperlipidemic Effects of Low-molecular-weight Carrageenan in Rats.Open life sciences · 2018Article
- Ameliorative effect of saffron aqueous extract on hyperglycemia, hyperlipidemia, and oxidative stress on diabetic encephalopathy in streptozotocin induced experimental diabetes mellitus.BioMed research international · 2014Article
- Extraction and Optimization of Active Metabolites From Cluster Bean: An In Vitro Biological and Phytochemical Investigation.Dose-response : a publication of International Hormesis SocietyArticle
- Catechin Treatment Ameliorates Diabetes and Its Complications in Streptozotocin-Induced Diabetic Rats.Dose-response : a publication of International Hormesis SocietyArticle
- Anti-diabetic effect of Capparis spinosa L. root extract in diabetic rats.Avicenna journal of phytomedicineArticle
Corrections and comments
- Erratum issuedSaeed, Samarghandian [corrected to Samarghandian, Saeed; Mosa-Al-Reza, Hadjzadeh [Hadjzadeh, Mosa-Al-Reza]; Fatemeh, Amin Nya [corrected to Amin Nya, Fatemeh]; Saeideh, Davoodi [corrected to Davoodi, Saeideh]
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHerbal medicine is widely used in the treatment of diseases like diabetes mellitus. We investigated the effects of guar gum in diabetic rats for the reduction of the risk of diabetes and cardiovascular disease. Dietary pattern emphasizing foods high in complex carbohydrates and fiber are associated with low blood glucose and cholesterol levels. MATERIALS AND
methodsDiet containing 0%, 5%, 10% and 20% (w/w) guar gum was fed to diabetic rats for 28 days. Blood serum glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol levels, atherogenic index levels, body weights and food intake were monitored at 0, 7.14 and 28 days after induction of diabetes.
resultsIn spite of the fact that diabetes elevated blood lipids in all rats after 14 days, the guar gum diet significantly decreased the serum concentration of cholesterol, triacylglicerols and LDL-C and atherogenic index. The most significant result in this study was the reduction of blood glucose in diabetic rats treated with the guar gum diet after 28 days versus non- and glibenclamide-treated rats. The gum promoted a general improvement in the condition of the diabetic rats in body weight and food intake in comparison with nontreated rats.
conclusionThe results of this research suggest that guar gum was significantly effective in comparison with glibenclamide in the treatment of hyperlipidemia and hyperglycemia in diabetes rats. Therefore, it may be suggested as a reliable fiber in diabetic regimes in diabetic patients.
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