ArticleJournal of oral and maxillofacial pathology : JOMFP2012
Oropharyngeal candidosis relative frequency in radiotherapy patient for head and neck cancer.
Article in Journal of oral and maxillofacial pathology : JOMFP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oral microbiota in head and neck cancer patients during radiotherapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- An Overview of How HNCs Radiotherapy Affects Oral Microbiota: Shifts, Complications, and Management Strategies.Journal of lasers in medical sciences · 2026Review
- Influence of Ubiquitin Mutations over Molecular Markers Contributing to Pathogenesis of Candida albicans.Cell biochemistry and biophysics · 2025Article
- Might photobiomodulation therapy interfere with the frequency of severe mucositis and oral candidiasis? A retrospective analysis in patients with head and neck carcinoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Investigating The Antifungal Activity of Atorvastatin Compared with Nystatin on Oral Candidiasis before and during Head and Neck Radiotherapy.Galen medical journal · 2024Review
- Antifungal effect of atorvastatin in comparison with fluconazole onDental research journal · 2024Article
- Comparison of oral candidiasis characteristics in head-and-neck cancer patients before and during radiotherapy.Dental research journal · 2023Article
- OralCancers · 2022Article
- A preliminary study of suppression of candida infection by miconazole mucoadhesive tablets in oral or oropharyngeal cancer patients undergoing radiotherapy.Scientific reports · 2022Article
- Species Diversity and Antifungal Susceptibilities of Oral Yeasts from Patients with Head and Neck Cancer.Infection and drug resistance · 2021Article
- Opportunistic Microorganisms in Oral Cavity According to Treatment Status in Head and Neck Cancer Patients.Journal of clinical and diagnostic research : JCDR · 2017Article
- Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- Biofilms of Candida albicans serotypes A and B differ in their sensitivity to photodynamic therapy.Lasers in medical science · 2014Article
- AnJournal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiation given during treatment of oral and pharyngeal malignancy frequently causes alteration of the oral environment predisposing to the colonization of the oral mucosa by yeast species most frequently Candida.
objectiveThus, this study was undertaken in 107 patients to find out association between radiation therapy and frequency of oropharyngeal candidosis, to quantitate colony forming units (CFUs) to identify Candida at species level and to check the incidence of serotype A and B in C. albicans. MATERIALS AND
methodsThe study was done on patients suffering from oropharyngeal cancer who were advised radiotherapy. The oral rinse collection method was used to collect the sample. Sabourauds Dextrose Agar (SDA) was used as primary culture media and subsequently speciation was done using standard techniques. The strains of C. albicans were serotyped employing the method described by Hansclever and Mitchell (1961, J Bacteriol 1961;82:570-3).
results26.16% patients were mycologically positive for candida before radiotherapy with CFUs 100. 14 ± 59.11 that increased to 60.74% patients during radiotherapy with an increase in CFUs to 490.15 ± 207.97. Clinically, grading of mucositis was done and also individual signs and symptoms were noted in each patient. The occurrence of erythmatous lesions, ulceration, and xerostomia were found to be statistically significant (P<0.05). C. albicans was the most frequently encountered species with higher prevalence of serotype A suggesting higher virulent species.
conclusionIt is proposed that in such patients taking radiotherapy prophylactic antifungal treatment should be given specially in patients showing development of oral mucosal lesions such as erythmatous lesions, ulcerations, and complaining about dryness of mouth, that is, xerostomia irrespective of presence or absence of clinical oral candidosis.
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