ArticleDiabetes2012
Resting-state brain networks in type 1 diabetic patients with and without microangiopathy and their relation to cognitive functions and disease variables.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Research trend of functional magnetic resonance imaging in diabetes mellitus research: a visualization and bibliometric analysis.Frontiers in neurologyPooled it
- Risk factors associated with cognitive performance and cognitive impairment in older adults with type 1 diabetes: Data from the Wireless Innovation for Seniors with Diabetes Mellitus (WISDM) study.Journal of diabetes and its complications · 2024Trial
- Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity.World journal of diabetes · 2021Trial
- The presence of cerebral white matter lesions and lower skin microvascular perfusion predicts lower cognitive performance in type 1 diabetes patients with retinopathy but not in healthy controls-A longitudinal study.Microcirculation (New York, N.Y. : 1994) · 2019Trial
- Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes.Diabetes · 2015Trial
- Reduced cortical gyrification in type 1 diabetes is associated with white matter integrity loss and cognitive decline.Metabolic brain disease · 2026Article
- Brain structural changes in diabetic retinopathy patients: a combined voxel-based morphometry and surface-based morphometry study.Brain imaging and behavior · 2024Article
- Aberrant Modular Segregation of Brain Networks in Patients with Diabetic Retinopathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Brain functional and structural changes in diabetic children. How can intellectual development be optimized in type 1 diabetes?Therapeutic advances in chronic disease · 2024Review
- Abnormal functional connectivity in radiologically isolated syndrome: A resting-state fMRI study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Amplitude of Low-Frequency Fluctuation to Determine Disturbed Spontaneous Brain-Activity Pattern in Patients with Diabetic Optic Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Comparison of cognitive function in older adults with type 1 diabetes, type 2 diabetes, and no diabetes: results from the Study of Longevity in Diabetes (SOLID).BMJ open diabetes research & care · 2022Article
- Cognitive Dysfunction in Type 2 Diabetes Is Not a One-Way Process: Evidence From a Longitudinal Brain Connectivity Study.Frontiers in endocrinology · 2022Article
- Concomitant functional impairment and reorganization in the linkage between the cerebellum and default mode network in patients with type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2021Article
- Invasion of phagocytic Galectin 3 expressing macrophages in the diabetic brain disrupts vascular repair.Science advances · 2021Article
- Inter-hemispheric Functional Connections Are More Vulnerable to Attack Than Structural Connection in Patients With Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2021Article
- ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes-Associated Cognitive DeclineFrontiers in cell and developmental biology · 2021Article
- Sex, diabetes status and cognition: findings from the study of longevity in diabetes.BMJ open diabetes research & care · 2021Article
- NMR-based metabolomics characterizes metabolic changes in different brain regions of streptozotocin-induced diabetic mice with cognitive decline.Metabolic brain disease · 2020Article
- Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory.Diabetes · 2020Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive functioning depends on intact brain networks that can be assessed with functional magnetic resonance imaging (fMRI) techniques. We hypothesized that cognitive decrements in type 1 diabetes mellitus (T1DM) are associated with alterations in resting-state neural connectivity and that these changes vary according to the degree of microangiopathy. T1DM patients with (MA(+): n = 49) and without (MA(-): n = 52) microangiopathy were compared with 48 healthy control subjects. All completed a neuropsychological assessment and resting-state fMRI. Networks were identified using multisubject independent component analysis; specific group differences within each network were analyzed using the dual-regression method, corrected for confounding factors and multiple comparisons. Relative to control subjects, MA(-) patients showed increased connectivity in networks involved in motor and visual processes, whereas MA(+) patients showed decreased connectivity in networks involving attention, working memory, auditory and language processing, and motor and visual processes. Better information-processing speed and general cognitive ability were related to increased degree of connectivity. T1DM is associated with a functional reorganization of neural networks that varies, dependent on the presence or absence of microangiopathy.
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