ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2012
A nonlinear model for hippocampal cognitive prosthesis: memory facilitation by hippocampal ensemble stimulation.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Neurosurgery and the Brain-Computer Interface.Advances in experimental medicine and biology · 2024Review
- Memory Prosthesis: Is It Time for a Deep Neuromimetic Computing Approach?Frontiers in neuroscience · 2019Article
- A Multi-Channel Asynchronous Neurostimulator With Artifact Suppression for Neural Code-Based Stimulations.Frontiers in neuroscience · 2019Article
- Optogenetic Stimulation of the Basolateral Amygdala Increased Theta-Modulated Gamma Oscillations in the Hippocampus.Frontiers in behavioral neuroscience · 2019Article
- Direct Stimulation of Human Hippocampus During Verbal Associative Encoding Enhances Subsequent Memory Recollection.Frontiers in human neuroscience · 2019Article
- Sparse Large-Scale Nonlinear Dynamical Modeling of Human Hippocampus for Memory Prostheses.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018Article
- Multiple Approaches to the Investigation of Cell Assembly in Memory Research-Present and Future.Frontiers in systems neuroscience · 2018Review
- A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain.Experimental neurology · 2017Article
- Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank.Frontiers in neuroscience · 2017Article
- Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Review
- Neurons and networks organizing and sequencing memories.Brain research · 2015Article
- Identification of functional synaptic plasticity from spiking activities using nonlinear dynamical modeling.Journal of neuroscience methods · 2015Article
- Distributed encoding of spatial and object categories in primate hippocampal microcircuits.Frontiers in neuroscience · 2015Article
- On parsing the neural code in the prefrontal cortex of primates using principal dynamic modes.Journal of computational neuroscience · 2014Article
- Deep brain stimulation for enhancement of learning and memory.NeuroImage · 2014Review
- Extraction and restoration of hippocampal spatial memories with non-linear dynamical modeling.Frontiers in systems neuroscience · 2014Article
- Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing.Journal of neural engineering · 2013Article
- A nonlinear autoregressive Volterra model of the Hodgkin-Huxley equations.Journal of computational neuroscience · 2013Article
- Nonlinear modeling of dynamic interactions within neuronal ensembles using Principal Dynamic Modes.Journal of computational neuroscience · 2013Article
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Authors and funding
10 authors.
Funding
Abstract
Collaborative investigations have characterized how multineuron hippocampal ensembles encode memory necessary for subsequent successful performance by rodents in a delayed nonmatch to sample (DNMS) task and utilized that information to provide the basis for a memory prosthesis to enhance performance. By employing a unique nonlinear dynamic multi-input/multi-output (MIMO) model, developed and adapted to hippocampal neural ensemble firing patterns derived from simultaneous recorded CA1 and CA3 activity, it was possible to extract information encoded in the sample phase necessary for successful performance in the nonmatch phase of the task. The extension of this MIMO model to online delivery of electrical stimulation delivered to the same recording loci that mimicked successful CA1 firing patterns, provided the means to increase levels of performance on a trial-by-trial basis. Inclusion of several control procedures provides evidence for the specificity of effective MIMO model generated patterns of electrical stimulation. Increased utility of the MIMO model as a prosthesis device was exhibited by the demonstration of cumulative increases in DNMS task performance with repeated MIMO stimulation over many sessions on both stimulation and nonstimulation trials, suggesting overall system modification with continued exposure. Results reported here are compatible with and extend prior demonstrations and further support the candidacy of the MIMO model as an effective cortical prosthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.