ArticleJournal of experimental botany2012
Auxin transport at cellular level: new insights supported by mathematical modelling.
Article in Journal of experimental botany, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Stem cell activity is linked to a transient acquisition of pluripotency during callus proliferation.Nature communications · 2026Article
- Membrane transport of root-borne trans-zeatin riboside maintains the cytokinin homeostasis in shoots.Journal of experimental botany · 2025Article
- ESR2-HDA6 complex negatively regulates auxin biosynthesis to delay callus initiation in Arabidopsis leaf explants during tissue culture.Plant communications · 2024Article
- PIN structures shed light on their mechanism of auxin efflux.Journal of experimental botany · 2023Article
- The differential binding and biological efficacy of auxin herbicides.Pest management science · 2023Article
- Sulfadiazine and phosphinothricin selection systems optimised for the transformation of tobacco BY-2 cells.Plant cell reports · 2023Article
- Article
- DIOXYGENASE FOR AUXIN OXIDATION 1 catalyzes the oxidation of IAA amino acid conjugates.Plant physiology · 2021Article
- Differential Subcellular Distribution of Cytokinins: How Does Membrane Transport Fit into the Big Picture?International journal of molecular sciences · 2021Review
- Intra and Extracellular Journey of the Phytohormone Salicylic Acid.Frontiers in plant science · 2019Review
- Advances in Understanding the Mechanism of Action of the Auxin Permease AUX1.International journal of molecular sciences · 2018Review
- Auxins and Cytokinins-The Role of Subcellular Organization on Homeostasis.International journal of molecular sciences · 2018Review
- Weed resistance to synthetic auxin herbicides.Pest management science · 2018Review
- Identification of Auxin Activity Like 1, a chemical with weak functions in auxin signaling pathway.Plant molecular biology · 2018Article
- What Has Been Seen Cannot Be Unseen-Detecting Auxin In Vivo.International journal of molecular sciences · 2017Review
- ACCERBATIN, a small molecule at the intersection of auxin and reactive oxygen species homeostasis with herbicidal properties.Journal of experimental botany · 2017Article
- Article
- Sirtinol, a Sir2 protein inhibitor, affects stem cell maintenance and root development in Arabidopsis thaliana by modulating auxin-cytokinin signaling components.Scientific reports · 2017Article
- The Allelochemical MDCA Inhibits Lignification and Affects Auxin Homeostasis.Plant physiology · 2016Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular basis of cellular auxin transport is still not fully understood. Although a number of carriers have been identified and proved to be involved in auxin transport, their regulation and possible activity of as yet unknown transporters remain unclear. Nevertheless, using single-cell-based systems it is possible to track the course of auxin accumulation inside cells and to specify and quantify some auxin transport parameters. The synthetic auxins 2,4-dichlorophenoxyacetic acid (2,4-D) and naphthalene-1-acetic acid (NAA) are generally considered to be suitable tools for auxin transport studies because they are transported specifically via either auxin influx or efflux carriers, respectively. Our results indicate that NAA can be metabolized rapidly in tobacco BY-2 cells. The predominant metabolite has been identified as NAA glucosyl ester and it is shown that all NAA metabolites were retained inside the cells. This implies that the transport efficiency of auxin efflux transporters is higher than previously assumed. By contrast, the metabolism of 2,4-D remained fairly weak. Moreover, using data on the accumulation of 2,4-D measured in the presence of auxin transport inhibitors, it is shown that 2,4-D is also transported by efflux carriers. These results suggest that 2,4-D is a promising tool for determining both auxin influx and efflux activities. Based on the accumulation data, a mathematical model of 2,4-D transport at a single-cell level is proposed. Optimization of the model provides estimates of crucial transport parameters and, together with its validation by successfully predicting the course of 2,4-D accumulation, it confirms the consistency of the present concept of cellular auxin transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.