ArticleBulletin of mathematical biology2012
A mathematical model of the enhancement of tumor vaccine efficacy by immunotherapy.
Article in Bulletin of mathematical biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 107 citations in OpenAlex.
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- Quantitative Approach to Explore Regulatory T Cell Activity in Immuno-Oncology.Pharmaceutics · 2024Review
- Modeling the Role of Immune Cell Conversion in the Tumor-Immune Microenvironment.Bulletin of mathematical biology · 2023Article
- Modeling cancer immunoediting in tumor microenvironment with system characterization through the ising-model Hamiltonian.BMC bioinformatics · 2022Article
- Mathematical model of a personalized neoantigen cancer vaccine and the human immune system.PLoS computational biology · 2021Article
- Quantitative Systems Pharmacology Approaches for Immuno-Oncology: Adding Virtual Patients to the Development Paradigm.Clinical pharmacology and therapeutics · 2021Review
- Fundamentals of Cancer Immunology and Their Application to Cancer Vaccines.Clinical and translational science · 2021Article
- Dependence of CD8 T Cell Response upon Antigen Load During Primary Infection : Analysis of Data from Yellow Fever Vaccination.Bulletin of mathematical biology · 2019Article
- Pharmacodynamic Drug-Drug Interactions.Clinical pharmacology and therapeutics · 2019Review
- Mathematical Modeling, Analysis, and Simulation of Tumor Dynamics with Drug Interventions.Computational and mathematical methods in medicine · 2019Article
- Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology.Frontiers in immunology · 2019Review
- Dynamics of Breast Cancer under Different Rates of Chemoradiotherapy.Computational and mathematical methods in medicine · 2019Article
- Optimization of combination therapy for chronic myeloid leukemia with dosing constraints.Journal of mathematical biology · 2018Article
- Modeling combination therapy for breast cancer with BET and immune checkpoint inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- TGF-beta 1 levels are associated with lymphocyte percentages in patients with lung cancer treated with radiation therapy.OncoTargets and therapy · 2018Article
- Addressing current challenges in cancer immunotherapy with mathematical and computational modelling.Journal of the Royal Society, Interface · 2017Review
- Dissect the Dynamic Molecular Circuits of Cell Cycle Control through Network Evolution Model.BioMed research international · 2017Article
- A cancer treatment based on synergy between anti-angiogenic and immune cell therapies.Journal of theoretical biology · 2016Article
- CD8(+) T cell response to adenovirus vaccination and subsequent suppression of tumor growth: modeling, simulation and analysis.BMC systems biology · 2015Article
- A mathematical model for pancreatic cancer growth and treatments.Journal of theoretical biology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
TGF-β is an immunoregulatory protein that contributes to inadequate antitumor immune responses in cancer patients. Recent experimental data suggests that TGF-β inhibition alone, provides few clinical benefits, yet it can significantly amplify the anti-tumor immune response when combined with a tumor vaccine. We develop a mathematical model in order to gain insight into the cooperative interaction between anti-TGF-β and vaccine treatments. The mathematical model follows the dynamics of the tumor size, TGF-β concentration, activated cytotoxic effector cells, and regulatory T cells. Using numerical simulations and stability analysis, we study the following scenarios: a control case of no treatment, anti-TGF-β treatment, vaccine treatment, and combined anti-TGF-β vaccine treatments. We show that our model is capable of capturing the observed experimental results, and hence can be potentially used in designing future experiments involving this approach to immunotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.