ArticleThe Plant cell2012
Ion exchangers NHX1 and NHX2 mediate active potassium uptake into vacuoles to regulate cell turgor and stomatal function in Arabidopsis.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 239 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
239 citing papers in PubMed, 1 synthesis or guideline pooled it, 618 citations in OpenAlex.
- Increased salt tolerance with overexpression of cation/proton antiporter 1 genes: a meta-analysis.Plant biotechnology journal · 2017Pooled it
- Laying the blueprint of abiotic stress tolerance: an analysis on the complexities of the stress matrix.Plant signaling & behavior · 2026Review
- Subcellular Potassium Ion-Mediated Structural Coordination Between Mesophyll Cells and Chloroplasts Determines COPlant, cell & environment · 2026Article
- Genomic and genetic dissection underlying seedling drought resilience in oats.Nature communications · 2026Article
- Multi-layered RNA decay mechanisms underlie subgenome-biased homoeologous mRNA stability in salt-stressed allopolyploid plants.The Plant journal : for cell and molecular biology · 2026Article
- Genome-wide identification and salt stress-induced expression analysis of the NHX gene family in peanut (Arachis hypogaea L.).BMC plant biology · 2026Article
- Nano-priming modulates antioxidant enzymes and NHX/SOS-mediated ion homeostasis to improve salinity tolerance in barley genotypes.Plant cell reports · 2026Article
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- Role of jasmonic acid and salicylic acid in salinity stress mitigation in plants.Frontiers in plant science · 2026Review
- Comparative transcriptome analysis revealed that tomato response to salt stress induced by exogenous GABA and functional verification of SlGAD1.BMC plant biology · 2025Article
- Vacuolar K⁺ efflux transporter TaTPK1-5D confers low-K⁺ tolerance of 'Zhengmai 136' through interaction with TaCIPK23-4D in bread wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Alfalfa MsSOS2 confers salinity tolerance by promoting lateral root growth and regulating NaScientific reports · 2025Article
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- Structural and Functional Characterization of the Vacuolar-Type NaBiomolecules · 2025Article
- ZxNHX1 from a xerophyte outperforms AtNHX1 in sequestering NaPlant biotechnology journal · 2025Article
- The phytochrome-interacting factor PIL13 enhances water use efficiency under fluctuating light and drought resilience in rice and soybean.Communications biology · 2025Article
- Genome-Wide Identification of theInternational journal of molecular sciences · 2025Article
- Dual roles of SOS1: NaPlant communications · 2025Article
179 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular NHX proteins are Na(+),K(+)/H(+) antiporters involved in K(+) homeostasis, endosomal pH regulation, and salt tolerance. Proteins NHX1 and NHX2 are the two major tonoplast-localized NHX isoforms. Here, we show that NHX1 and NHX2 have similar expression patterns and identical biochemical activity, and together they account for a significant amount of the Na(+),K(+)/H(+) antiport activity in tonoplast vesicles. Reverse genetics showed functional redundancy of NHX1 and NHX2 genes. Growth of the double mutant nhx1 nhx2 was severely impaired, and plants were extremely sensitive to external K(+). By contrast, nhx1 nhx2 mutants showed similar sensitivity to salinity stress and even greater rates of Na(+) sequestration than the wild type. Double mutants had reduced ability to create the vacuolar K(+) pool, which in turn provoked greater K(+) retention in the cytosol, impaired osmoregulation, and compromised turgor generation for cell expansion. Genes NHX1 and NHX2 were highly expressed in guard cells, and stomatal function was defective in mutant plants, further compromising their ability to regulate water relations. Together, these results show that tonoplast-localized NHX proteins are essential for active K(+) uptake at the tonoplast, for turgor regulation, and for stomatal function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.