ArticleNucleic acids research1990
A highly conserved enhancer downstream of the human MLC1/3 locus is a target for multiple myogenic determination factors.
Article in Nucleic acids research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 96 citations in OpenAlex.
- Adaptive changes in the DNA damage response during skeletal muscle cell differentiation.Frontiers in cell and developmental biology · 2023Article
- Association of HOMER1 rs2290639 with suicide attempts in Hong Kong Chinese and the potentially functional role of this polymorphism.SpringerPlus · 2016Article
- The role of MyoD1 and histone modifications in the activation of muscle enhancers.Epigenetics · 2013Article
- Enhancer-promoter interference and its prevention in transgenic plants.Plant cell reports · 2011Review
- Chromatin immunoprecipitation assay for tissue-specific genes using early-stage mouse embryos.Journal of visualized experiments : JoVE · 2011Article
- Both the constitutive cauliflower mosaic virus 35S and tissue-specific AGAMOUS enhancers activate transcription autonomously in Arabidopsis thaliana.Plant molecular biology · 2010Article
- Functional conservation between rodents and chicken of regulatory sequences driving skeletal muscle gene expression in transgenic chickens.BMC developmental biology · 2010Article
- Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3.The Journal of biological chemistry · 2009Article
- Aberrant development of motor axons and neuromuscular synapses in MyoD-null mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Maturation of the myogenic program is induced by postmitotic expression of insulin-like growth factor I.Molecular and cellular biology · 1999Article
- The myogenic regulatory circuit that controls cardiac/slow twitch troponin C gene transcription in skeletal muscle involves E-box, MEF-2, and MEF-3 motifs.Gene expression · 1999Article
- A novel E1A domain mediates skeletal-muscle-specific enhancer repression independently of pRB and p300 binding.Molecular and cellular biology · 1996Article
- Proliferation precedes differentiation in IGF-I-stimulated myogenesis.The Journal of cell biology · 1996Article
- Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus.Molecular and cellular biology · 1996Article
- Differences between MyoD DNA binding and activation site requirements revealed by functional random sequence selection.Molecular and cellular biology · 1996Article
- Distinct regulatory elements control muscle-specific, fiber-type-selective, and axially graded expression of a myosin light-chain gene in transgenic mice.Molecular and cellular biology · 1996Article
- Quantitative discrimination of MEF2 sites.Molecular and cellular biology · 1996Article
- Activation of a muscle-specific enhancer by the Ski proto-oncogene.Nucleic acids research · 1995Article
- Regulation of a muscle-specific transgene by retinoic acid.The Journal of cell biology · 1995Article
- Myosin light chain 3F regulatory sequences confer regionalized cardiac and skeletal muscle expression in transgenic mice.The Journal of cell biology · 1995Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A potent muscle-specific enhancer element, originally described in the rat myosin light chain (MLC) 1/3 locus located downstream of the coding region, is found in an analogous position in the human MLC1/3 gene. When linked to a CAT reporter gene and transfected into muscle or non-muscle cells, the human MLC enhancer directs high levels of muscle-specific gene expression from homologous or heterologous promoters, irrespective of position or orientation relative to the CAT transcription unit. A significant degree of sequence homology (over 85%) in the 3'-flanking regions of the two MLC genes is restricted to a 200 bp sequence which lies approximately 1.5 kb downstream of the polyadenylation site in both species. The human enhancer sequence includes binding sites for human myogenic determination factors containing a common basic helix-loop-helix motif, and it can be trans-activated to varying degrees in non-muscle cells by these factors. This study establishes the MLC enhancer as an evolutionarily conserved, integral component of the MLC1/3 locus which constitutes a novel target for the action of myogenic determination factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.