ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2012
Nutraceutical preparations in childhood migraine prophylaxis: effects on headache outcomes including disability and behaviour.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review Suggests Nutraceuticals Containing Vitamin B2 Could Provide an Alternative Treatment for Paediatric Migraines.Acta paediatrica (Oslo, Norway : 1992) · 2025Pooled it
- Trial
- Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014Trial
- Episodic Migraine in the Pediatric Population: Behavioral Therapies and other Non-Pharmacological Treatment Options.Current pain and headache reports · 2025Review
- Pediatric Headache in Primary Care and Emergency Departments: Consensus with RAND/UCLA Method.Life (Basel, Switzerland) · 2022Article
- Complementary and Integrative Medicines as Prophylactic Agents for Pediatric Migraine: A Narrative Literature Review.Journal of clinical medicine · 2021Review
- Prophylactic Treatment of Pediatric Migraine: Is There Anything New in the Last Decade?Frontiers in neurology · 2019Review
- The use of nutraceutics in children's and adolescent's headache.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Visual-spatial training efficacy in children affected by migraine without aura: a multicenter study.Neuropsychiatric disease and treatment · 2017Article
- The Rorschach Test Evaluation in Chronic Childhood Migraine: A Preliminary Multicenter Case-Control Study.Frontiers in neurology · 2017Article
- Behavioral management of headache in children and adolescents.The journal of headache and pain · 2016Review
- Spotlight on frovatriptan: a review of its efficacy in the treatment of migraine.Drug design, development and therapy · 2016Review
- Microemulsion of babassu oil as a natural product to improve human immune system function.Drug design, development and therapy · 2015Article
- Herbal therapy in migraine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Review
- Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18.Drug design, development and therapy · 2014Article
- Orthodontic treatment need for adolescents in the Campania region: the malocclusion impact on self-concept.Patient preference and adherence · 2014Article
- Generation of superoxide anion radicals and platelet glutathione peroxidase activity in patients with schizophrenia.Neuropsychiatric disease and treatment · 2014Article
- Decreased mean platelet volume in panic disorder.Neuropsychiatric disease and treatment · 2014Article
- Phyllostachys edulis extract induces apoptosis signaling in osteosarcoma cells, associated with AMPK activation.Drug design, development and therapy · 2014Article
- Nutraceuticals safety and efficacy in migraine without aura in a population of children affected by neurofibromatosis type I.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Migraine is common in children, but few specific drugs are available. We performed an open-label comparison of effects of two nutraceutical preparations (ginkgolide B vs. Griffonia simplicifolia extract) on outcomes in 374 school-age children (mean 10.7 years) with migraine without aura. Half of them received ginkgolide B; and half, Griffonia simplicifolia. Both preparations were given orally twice a day for 6 months. Patients kept a headache diary. Outcomes at the beginning and end of treatment were compared. Both preparations reduced all outcome measures after 6 months of treatment. However, reductions in headache frequency, duration and intensity, PedMIDAS score and behavioural reactions to headache were significantly greater in the ginkgolide B group. Both nutraceutical treatments appear promising in paediatric migraine without aura, particularly because of their lack of side effects. However, the ginkgolide B preparation was significantly more effective in the medium-term (6 months).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.