ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2012
Nonhuman primate models of stroke for translational neuroprotection research.
Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Preclinical evidence of remote ischemic conditioning in ischemic stroke, a metanalysis update.Scientific reports · 2021Pooled it
- Effect of uric acid in animal models of ischemic stroke: A systematic review and meta-analysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Pre-Clinical Testing of Therapies for Traumatic Brain Injury.Journal of neurotrauma · 2018Guideline
- Enhanced motor recovery in stroke patients through dual-modal intervention: motor imagery and task-oriented robot training.Journal of neuroengineering and rehabilitation · 2025Trial
- Animal models of multi-infarct dementia: Methodological approaches, neuropathology, functional outcomes, and translational relevance.Experimental neurology · 2026Review
- Signatures of Covert Neuron Loss in the Local Field Potential of Motor Cortex.Journal of the American Heart Association · 2026Article
- Pre-Clinical Models of Traumatic Brain Injury-A Narrative Review Towards "Animal Neuro-ICUs".Biomedicines · 2026Review
- Ischemic Stroke in a Talapoin Monkey (Miopithecus talapoin).Journal of medical primatology · 2026Article
- Human Stem Cell-Derived Extracellular Vesicles: A Pioneering Path from Biogenesis to Cerebral Ischemic Stroke Therapy.International journal of molecular sciences · 2025Review
- A Scoping Review of Preclinical Environmental Enrichment Protocols in Models of Poststroke to Set the Foundations for Translating the Paradigm to Clinical Settings.Translational stroke research · 2025Article
- 3D ultrasound localization microscopy of the nonhuman primate brain.EBioMedicine · 2025Article
- Changes in cortical manifold structure following stroke and its relation to behavioral recovery in the male macaque.Nature communications · 2024Article
- Pterion variation in the skulls of rhesus macaques from Cayo Santiago: Inheritance, development, and pathology.Anatomical record (Hoboken, N.J. : 2007) · 2024Article
- Nerinetide Reduces Early Infarct Growth Among Stroke Patients Undergoing EVT Without Intravenous Alteplase.Stroke (Hoboken, N.J.) · 2024Article
- Spontaneous Behavioural Recovery Following Stroke Relates to the Integrity of Parietal and Temporal Regions.Translational stroke research · 2024Article
- Revisiting Transcranial Light Stimulation as a Stroke Therapeutic-Hurdles and Opportunities.Translational stroke research · 2023Review
- Non-human primate models of focal cortical ischemia for neuronal replacement therapy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Review
- Quantitative Evaluation of Oxygen Extraction Fraction Changes in the Monkey Brain during Acute Stroke by Using Quantitative Susceptibility Mapping.Life (Basel, Switzerland) · 2023Article
- Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents.Acta pharmacologica Sinica · 2023Article
- Neurological scoring and gait kinematics to assess functional outcome in an ovine model of ischaemic stroke.Frontiers in neurology · 2023Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the discovery of several promising neuroprotective therapies in rodent models of stroke, no therapy other than the fibrinolytics has been found to be effective in human clinical trials. To address potential discrepancies between rodent and human studies, the Stroke Therapy Academic Industry Roundtable (STAIR) committee suggested that nonhuman primates (NHPs) be used for preclinical, translational stroke studies. Due to the paucity of stroke studies in NHPs, few experimental models have been described. Critical factors in designing NHP stroke models include the choice of species, the method of inducing the stroke and the choice of outcome measures. In this review, we describe established NHP models of stroke and discuss factors that may influence model development with a focus on models that may be useful in preclinical studies for neuroprotective drug screening prior to clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.