ArticleRadiation and environmental biophysics2012
Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.
Article in Radiation and environmental biophysics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Ionising radiation and cardiovascular disease: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2023Pooled it
- Radiation and circulatory disease.Mutation research. Reviews in mutation researchPooled it
- Comparison and multi-model inference of excess risks models for radiation-related solid cancer.Radiation and environmental biophysics · 2023Article
- Summary of Radiation Research Society Online 66th Annual Meeting, Symposium on "Epidemiology: Updates on epidemiological low dose studies," including discussion.International journal of radiation biology · 2021Article
- Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology.International journal of radiation biology · 2021Review
- Dose limits for occupational exposure to ionising radiation and genotoxic carcinogens: a German perspective.Radiation and environmental biophysics · 2020Review
- Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study.Radiation and environmental biophysics · 2020Article
- Methods to account for uncertainties in exposure assessment in studies of environmental exposures.Environmental health : a global access science source · 2019Review
- Dose-responses for mortality from cerebrovascular and heart diseases in atomic bomb survivors: 1950-2003.Radiation and environmental biophysics · 2018Article
- Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review).International journal of molecular medicine · 2016Review
- Circulatory disease mortality in the Massachusetts tuberculosis fluoroscopy cohort study.European journal of epidemiology · 2016Article
- Low dose radiation and circulatory diseases: a brief narrative review.Cardio-oncology (London, England) · 2015Review
- Simulation-extrapolation method to address errors in atomic bomb survivor dosimetry on solid cancer and leukaemia mortality risk estimates, 1950-2003.Radiation and environmental biophysics · 2015Article
- Cerebrovascular Diseases in Workers at Mayak PA: The Difference in Radiation Risk between Incidence and Mortality.PloS one · 2015Article
- Ischemic heart disease in workers at Mayak PA: latency of incidence risk after radiation exposure.PloS one · 2014Article
- Article
- Cardiovascular effects after low-dose exposure and radiotherapy: what research is needed?Radiation and environmental biophysics · 2013Article
- A review of non-cancer effects, especially circulatory and ocular diseases.Radiation and environmental biophysics · 2013Review
- How is the risk of radiation-induced cancer influenced by background risk factors? Invited commentary on "a method for determining weights for excess relative risk and excess absolute risk when applied in the calculation of lifetime risk of cancer from radiation exposure" by Walsh and Schneider (2012).Radiation and environmental biophysics · 2013Article
- External gamma radiation and mortality from cardiovascular diseases in the German WISMUT uranium miners cohort study, 1946-2008.Radiation and environmental biophysics · 2013Article
Corrections and comments
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- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various parametric and categorical models (such as linear-no-threshold (LNT) and a number of threshold and step models) were analysed with a statistical selection protocol that rated the model description of the data. Instead of applying the usual approach of identifying one preferred model for each data set, a set of plausible models was applied, and a sub-set of non-nested models was identified that all fitted the data about equally well. Subsequently, this sub-set of non-nested models was used to perform multi-model inference (MMI), an innovative method of mathematically combining different models to allow risk estimates to be based on several plausible dose-response models rather than just relying on a single model of choice. This procedure thereby produces more reliable risk estimates based on a more comprehensive appraisal of model uncertainties. For CVD, MMI yielded a weak dose-response (with a risk estimate of about one-third of the LNT model) below a step at 0.6 Gy and a stronger dose-response at higher doses. The calculated risk estimates are consistent with zero risk below this threshold-dose. For mortalities related to cardiovascular diseases, an LNT-type dose-response was found with risk estimates consistent with zero risk below 2.2 Gy based on 90% confidence intervals. The MMI approach described here resolves a dilemma in practical radiation protection when one is forced to select between models with profoundly different dose-responses for risk estimates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.