ArticleJournal of neuropathology and experimental neurology2012
Somatostatin and neuropeptide Y neurons undergo different plasticity in parahippocampal regions in kainic acid-induced epilepsy.
Article in Journal of neuropathology and experimental neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Somatic mosaicism and interneuron involvement in mTORopathies.Trends in neurosciences · 2025Review
- Intranasal neuropeptide Y1 receptor antagonism improves motor deficits in symptomatic SOD1 ALS mice.Annals of clinical and translational neurology · 2023Article
- Spatial Distribution of Inhibitory Innervations of Excitatory Pyramidal Cells by Major Interneuron Subtypes in the Auditory Cortex.Bioengineering (Basel, Switzerland) · 2023Article
- Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy.Frontiers in cellular neuroscience · 2023Article
- Discrete subicular circuits control generalization of hippocampal seizures.Nature communications · 2022Article
- Somatostatin and Somatostatin-Containing Interneurons-From Plasticity to Pathology.Biomolecules · 2022Review
- Seizure-induced overexpression of NPY induces epileptic tolerance in a mouse model of spontaneous recurrent seizures.Frontiers in molecular neuroscience · 2022Article
- Alterations of Neuronal Dynamics as a Mechanism for Cognitive Impairment in Epilepsy.Current topics in behavioral neurosciences · 2022Review
- A Model of Chronic Temporal Lobe Epilepsy Presenting Constantly Rhythmic and Robust Spontaneous Seizures, Co-morbidities and Hippocampal Neuropathology.Aging and disease · 2019Article
- Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research.Frontiers in cellular neuroscience · 2018Review
- Dysregulation of zinc/lipid metabolism‑associated genes in the rat hippocampus and cerebral cortex in early adulthood following recurrent neonatal seizures.Molecular medicine reports · 2017Article
- Selective Silencing of Hippocampal Parvalbumin Interneurons Induces Development of Recurrent Spontaneous Limbic Seizures in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Calretinin and Neuropeptide Y interneurons are differentially altered in the motor cortex of the SOD1Scientific reports · 2017Article
- Expression of class II histone deacetylases in two mouse models of temporal lobe epilepsy.Journal of neurochemistry · 2016Article
- Persistent Hyperactivity of Hippocampal Dentate Interneurons After a Silent Period in the Rat Pilocarpine Model of Epilepsy.Frontiers in cellular neuroscience · 2016Article
- Layer-specific modulation of entorhinal cortical excitability by presubiculum in a rat model of temporal lobe epilepsy.Journal of neurophysiology · 2015Article
- Beyond the hammer and the scalpel: selective circuit control for the epilepsies.Nature neuroscience · 2015Article
- Old-onset caloric restriction effects on neuropeptide Y- and somatostatin-containing neurons and on cholinergic varicosities in the rat hippocampal formation.Age (Dordrecht, Netherlands) · 2014Article
- How might novel technologies such as optogenetics lead to better treatments in epilepsy?Advances in experimental medicine and biology · 2014Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Parahippocampal brain areas including the subiculum, presubiculum and parasubiculum, and entorhinal cortex give rise to major input and output neurons of the hippocampus and exert increased excitability in animal models and human temporal lobe epilepsy. Using immunohistochemistry and in situ hybridization for somatostatin and neuropeptide Y, we investigated plastic morphologic and neurochemical changes in parahippocampal neurons in the kainic acid (KA) model of temporal lobe epilepsy. Although constitutively contained in similar subclasses of γ-aminobutyric acid (GABA)-ergic neurons, both neuropeptide systems undergo distinctly different changes in their expression. Somatostatin messenger RNA (mRNA) is rapidly but transiently expressed de novo in pyramidal neurons of the subiculum and entorhinal cortex 24 hours after KA. Surviving somatostatin interneurons display increased mRNA levels at late intervals (3 months) after KA and increased labeling of their terminals in the outer molecular layer of the subiculum; the labeling correlates with the number of spontaneous seizures, suggesting that the seizures may trigger somatostatin expression. In contrast, neuropeptide Y mRNA is consistently expressed in principal neurons of the proximal subiculum and the lateral entorhinal cortex and labeling for the peptide persistently increased in virtually all major excitatory pathways of the hippocampal formation. The pronounced plastic changes differentially involving both neuropeptide systems indicate marked rearrangement of parahippocampal areas, presumably aiming at endogenous seizure protection. Their receptors may be targets for anticonvulsive drug therapy.
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