ArticleEuropean archives of psychiatry and clinical neuroscience2012
Antisaccade performance in patients with obsessive-compulsive disorder and unaffected relatives: further evidence for impaired response inhibition as a candidate endophenotype.
Article in European archives of psychiatry and clinical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Antisaccade Performance in Adolescent Obsessive-Compulsive Disorder: Evidence from a Familial-Risk Design.Journal of eye movement research · 2026Article
- Sensorimotor and inhibitory control in agingFrontiers in human neuroscience · 2023Article
- Neural Correlates of Executive Functioning in Anorexia Nervosa and Obsessive-Compulsive Disorder.Frontiers in human neuroscience · 2022Review
- Specific Aspects of Eye Movement Reactions as Markers of Cognitive Control Disorders in Patients with Obsessive-Compulsive Disorder (Review).Sovremennye tekhnologii v meditsine · 2022Review
- Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls.Scientific reports · 2021Observational
- Neurocognitive Endophenotypes of OCD.Current topics in behavioral neurosciences · 2021Article
- Towards Clinically Relevant Oculomotor Biomarkers in Early Schizophrenia.Frontiers in behavioral neuroscience · 2021Article
- The effects of selective serotonin reuptake inhibitors on brain functional networks during goal-directed planning in obsessive-compulsive disorder.Scientific reports · 2020Article
- Cognitive performance in children and adolescents at high-risk for obsessive-compulsive disorder.BMC psychiatry · 2020Article
- Article
- A pilot study examining the use of Goal Management Training in individuals with obsessive-compulsive disorder.Pilot and feasibility studies · 2020Article
- How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach.Annals of general psychiatry · 2020Review
- Schizotypy and smooth pursuit eye movements as potential endophenotypes of obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2019Article
- Impaired Antisaccades in Obsessive-Compulsive Disorder: Evidence From Meta-Analysis and a Large Empirical Study.Frontiers in psychiatry · 2018Article
- Mechanisms of saccade suppression revealed in the anti-saccade task.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Cognitive Dysfunction in Obsessive-Compulsive Disorder.Current psychiatry reports · 2016Review
- Saccadic Eye Movements in Anorexia Nervosa.PloS one · 2016Article
- Obsessive-compulsive disorder is associated with broad impairments in executive function: A meta-analysis.Clinical psychological science : a journal of the Association for Psychological Science · 2015Article
- Subcortical and cortical morphological anomalies as an endophenotype in obsessive-compulsive disorder.Molecular psychiatry · 2015Article
- Aberrant error processing in relation to symptom severity in obsessive-compulsive disorder: A multimodal neuroimaging study.NeuroImage. Clinical · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive dysfunctions such as inhibitory deficits and visuospatial abnormalities are often found in patients with obsessive-compulsive disorder (OCD). Recent findings in unaffected relatives indicate that response inhibition and other neuropsychological functions may also constitute endophenotypes of OCD. In the present study, 30 OCD patients, 30 first-degree relatives, and 30 healthy control subjects were assessed using a comprehensive neuropsychological test battery. A subsample of 21 subjects of each group also performed an antisaccade task. The samples were matched according to age, gender, education, and verbal intelligence. The OCD patients and the unaffected OCD relatives showed increased antisaccade error rates compared with the healthy control group (p = 0.003, p = 0.028, respectively). Significantly prolonged antisaccade latencies as compared to prosaccade latencies were only found in the OCD patients compared with the healthy control group (p = 0.019). Only OCD patients but not the unaffected OCD relatives were impaired with regard to visuospatial functions, problem-solving, and processing speed. Antisaccade errors did not correlate with severity of OCD or depressive symptoms. This study confirms inhibitory deficits, as indicated by increased antisaccade error rates, as a candidate endophenotype of OCD. In agreement with previous findings from imaging studies, our data suggest that functional abnormalities in frontostriatal and parietal cortical regions form part of the vulnerability for OCD.
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