ArticleBMC urology2012
Severe paraneoplastic hypereosinophilia in metastatic renal cell carcinoma.
Article in BMC urology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Prevalence and risk factors of persistent cough in patients diagnosed with renal cell carcinoma: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Severe eosinophilia and risk of major disease and mortality: A nationwide cohort study of children and adults.The journal of allergy and clinical immunology. Global · 2026Article
- Associated diagnostic spectrum and stratified characteristics of patients with eosinophilia: a retrospective study.Frontiers in medicine · 2026Article
- Successful treatment of eosinophilia associated with dialysis-related renal cancer with radical nephrectomy.IJU case reports · 2024Article
- Article
- Literature reviews of stroke with hypereosinophilic syndrome.International journal of cardiology. Heart & vasculature · 2021Review
- Multiple cerebral infarctions associated with lung cancer-induced hypereosinophilia: a case report.BMC neurology · 2021Article
- Hypereosinophilia in Solid Tumors-Case Report and Clinical Review.Frontiers in oncology · 2021Article
- Loeffler Endocarditis as a Manifestation of Paraneoplastic Hypereosinophilia.CASE (Philadelphia, Pa.) · 2020Article
- Eosinophilic Myocarditis: Classic Presentation of Elusive Disease.Circulation. Cardiovascular imaging · 2019Article
- Eosinophilia and Kidney Disease: More than Just an Incidental Finding?Journal of clinical medicine · 2018Review
- Rare and changeable as a chameleon: paraneoplastic syndromes in renal cell carcinoma.World journal of urology · 2018Review
- Cytokine Measurements for Diagnosing and Characterizing Leukemoid Reactions and Immunohistochemical Validation of a Granulocyte Colony-Stimulating Factor and CXCL8-Producing Renal Cell Carcinoma.Biomarker insights · 2018Article
- Impact of chemotherapy on eosinophilia-associated advanced rectal cancer: A case report and review of the literature.Oncology letters · 2016Article
- Chromophobe renal cell carcinoma associated with eosinophilia: A report of three cases.Experimental and therapeutic medicine · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRenal cell carcinoma can cause various paraneoplastic syndromes including metabolic and hematologic disturbances. Paraneoplastic hypereosinophilia has been reported in a variety of hematologic and solid tumors. We present the first case in the literature of severe paraneoplastic hypereosinophilia in a patient with renal cell carcinoma. CASE PRESENTATION: A 46 year-old patient patient with a history of significant weight loss, reduced general state of health and coughing underwent radical nephrectomy for metastasized renal cell carcinoma. Three weeks after surgery, the patient presented with excessive peripheral hypereosinophilia leading to profound neurological symptoms due to cerebral microinfarction. Systemic treatment with prednisolone, hydroxyurea, vincristine, cytarabine, temsirolimus and sunitinib led to reduction of peripheral eosinophils but could not prevent rapid disease progression of the patient. At time of severe leukocytosis, a considerable increase of cytokines associated with hypereosinophilia was measurable.
conclusionsParaneoplastic hypereosinophilia in patients with renal cell carcinoma might indicate poor prognosis and rapid disease progression. Myelosuppressive therapy is required in symptomatic patients.
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