Trial reportJournal of cardiothoracic surgery2012
Ondasetron versus haloperidol for the treatment of postcardiotomy delirium: a prospective, randomized, double-blinded study.
Trial report in Journal of cardiothoracic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Haloperidol for the treatment of delirium in critically ill patients: an updated systematic review with meta-analysis and trial sequential analysis.Critical care (London, England) · 2023Pooled it
- Pharmacological interventions for the treatment of delirium in critically ill adults.The Cochrane database of systematic reviews · 2019Pooled it
- Pooled it
- Trial
- Haloperidol prophylaxis for preventing aggravation of postoperative delirium in elderly patients: a randomized, open-label prospective trial.Surgery today · 2017Trial
- Haloperidol prophylaxis does not prevent postoperative delirium in elderly patients: a randomized, open-label prospective trial.Surgery today · 2014Trial
- Advancing Delirium Treatment Trials in Older Adults: Recommendations for Future Trials From the Network for Investigation of Delirium: Unifying Scientists (NIDUS).Critical care medicine · 2025Article
- Intraoperative 5-HTJournal of anesthesia · 2023Article
- 5-HTPerioperative medicine (London, England) · 2021Article
- Efficacy of Ondansetron in the Prevention or Treatment of Post-operative Delirium-a Systematic Review.Canadian geriatrics journal : CGJ · 2019Review
- Haloperidol Use Among Elderly Patients Undergoing Surgery: A Retrospective 1-Year Study in a Hospital Population.Drugs - real world outcomes · 2016Article
- Update on Pharmacotherapy for Prevention and Treatment of Post-operative Delirium: A Systematic Evidence Review.Current anesthesiology reports · 2015Article
- Management of delirium in palliative care: a review.Current psychiatry reports · 2015Review
- Delirium in patients with cancer: assessment, impact, mechanisms and management.Nature reviews. Clinical oncology · 2015Review
- Treating an established episode of delirium in palliative care: expert opinion and review of the current evidence base with recommendations for future development.Journal of pain and symptom management · 2014Review
- Delirium in the cardiac surgical ICU.Current opinion in anaesthesiology · 2014Review
- Comprehensive approaches to managing delirium in patients with advanced cancer.Cancer treatment reviews · 2013Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate the controlling efficacy of ondasetron and haloperidol in regard to the postcardiotomy delirium.
methodsWe included in this prospective, randomized, double-blinded study 80 patients who developed delirium after heart surgery with the application of heart lung-machine. The patients were divided into two, equally-sized groups, which on detection of delirium received ondasetron 8 mg iv or haloperidol 5 mg iv respectively. The statistical analysis compared the baseline and demographic characteristics of the two groups (age, gender, comorbidities, years of education, type of surgery etc.).
resultsBoth ondasetron and haloperidol had very good delirium controlling effects, without statistically significant differences. DISCUSSION-
conclusionsOndasetron and haloperidol are efficient agents as far as the treatment of postcardiotomy delirium is concerned. As, in addition, ondasetron bares milder side-effects, we believe this could be the agent of choice in patients developing postcardiotomy delirium in the future.
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