ArticleEnvironmental health perspectives2012
Inorganic arsenic and basal cell carcinoma in areas of Hungary, Romania, and Slovakia: a case-control study.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Exposure to Trace Elements and Risk of Skin Cancer: A Systematic Review of Epidemiologic Studies.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Pooled it
- The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence.Environmental health perspectives · 2017Pooled it
- Drinking Water Arsenic Contamination, Skin Lesions, and Malignancies: A Systematic Review of the Global Evidence.Current environmental health reports · 2015Pooled it
- Arsenic in drinking water and urinary tract cancers: a systematic review of 30 years of epidemiological evidence.Environmental health : a global access science source · 2014Pooled it
- A dietary-wide association study (DWAS) of environmental metal exposure in US children and adults.PloS one · 2014Trial
- Baseline comorbidities in a skin cancer prevention trial in Bangladesh.European journal of clinical investigation · 2013Trial
- Article
- Co-administration of L-Ascorbic Acid and α-Tocopherol Alleviates Arsenic-Induced Immunotoxicities in the Thymus and Spleen by Dwindling Oxidative Stress-Induced Inflammation.Biological trace element research · 2024Article
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Article
- Ambient UVR and Environmental Arsenic Exposure in Relation to Cutaneous Melanoma in Iowa.International journal of environmental research and public health · 2022Article
- Ultraviolet Radiation and Basal Cell Carcinoma: An Environmental Perspective.Frontiers in public health · 2021Review
- Basal Cell Carcinoma of the External Genitalia: A Population-Based Analysis.Frontiers in oncology · 2020Article
- Biomonitoring of metals and trace elements in urine of central Ethiopian populations.International journal of hygiene and environmental health · 2019Article
- Health effects among a cohort exposed to low-level arsenic in a geothermal area of Tuscany, Italy.International archives of occupational and environmental health · 2018Article
- Hazard Ranking Method for Populations Exposed to Arsenic in Private Water Supplies: Relation to Bedrock Geology.International journal of environmental research and public health · 2017Article
- Assessment of human dietary exposure to arsenic through rice.The Science of the total environment · 2017Review
- Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties.The Science of the total environment · 2017Article
- Variability in the chemistry of private drinking water supplies and the impact of domestic treatment systems on water quality.Environmental geochemistry and health · 2016Article
- Arsenic and subclinical vascular damage in a sample of Italian young adults: a cross-sectional analysis.Environmental science and pollution research international · 2016Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInorganic arsenic (iAs) is a potent carcinogen, but there is a lack of information about cancer risk for concentrations < 100 μg/L in drinking water.
objectivesWe aimed to quantify skin cancer relative risks in relation to iAs exposure < 100 μg/L and the modifying effects of iAs metabolism.
methodsThe Arsenic Health Risk Assessment and Molecular Epidemiology (ASHRAM) study, a case-control study, was conducted in areas of Hungary, Romania, and Slovakia with reported presence of iAs in groundwater. Consecutively diagnosed cases of basal cell carcinoma (BCC) of the skin were histologically confirmed; controls were general surgery, orthopedic, and trauma patients who were frequency matched to cases by age, sex, and area of residence. Exposure indices were constructed based on information on iAs intake over the lifetime of participants. iAs metabolism status was classified based on urinary concentrations of methylarsonic acid (MA) and dimethylarsinic acid (DMA). Associations were estimated by multivariable logistic regression.
resultsA total of 529 cases with BCC and 540 controls were recruited for the study. BCC was positively associated with three indices of iAs exposure: peak daily iAs dose rate, cumulative iAs dose, and lifetime average water iAs concentration. The adjusted odds ratio per 10-μg/L increase in average lifetime water iAs concentration was 1.18 (95% confidence interval: 1.08, 1.28). The estimated effect of iAs on cancer was stronger in participants with urinary markers indicating incomplete metabolism of iAs: higher percentage of MA in urine or a lower percentage of DMA.
conclusionWe found a positive association between BCC and exposure to iAs through drinking water with concentrations < 100 μg/L.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.