ReviewJournal of cellular and molecular medicine2012
Tissue engineering and regenerative medicine -where do we stand?
Review in Journal of cellular and molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04001842 (Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes), which is not on this map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mandibular Reconstruction Using Tissue Regeneration With Axially Vascularised Bone Substitutes
Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
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- Bioactive glass-ceramic bone repair associated or not with autogenous bone: a study of organic bone matrix organization in a rabbit critical-sized calvarial model.Clinical oral investigations · 2019Article
- Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies-A Quest forFrontiers in bioengineering and biotechnology · 2019Article
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- Telocytes and Their Extracellular Vesicles-Evidence and Hypotheses.International journal of molecular sciences · 2016Review
- Selective isolation and characterization of primary cells from normal breast and tumors reveal plasticity of adipose derived stem cells.Breast cancer research : BCR · 2016Article
- Penile reconstruction with dermal template and vacuum therapy in severe skin and soft tissue defects caused by Fournier's gangrene and hidradenitis suppurativa.International wound journal · 2016Article
- Emergency arterio-venous loop for free-flap defect reconstruction of the lower thigh with a post-irradiated and heavily infected wound.International wound journal · 2015Article
- Management of chronic osteomyelitis of the tibia with life-threatening complications under negative pressure wound therapy and isolation of Helcococcus kunzii.International wound journal · 2015Article
- Telocytes in regenerative medicine.Journal of cellular and molecular medicine · 2015Review
- Tissue engineering in burn scar reconstruction.Burns & trauma · 2015Review
- PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat.BMC biotechnology · 2014Article
- A hundred patients with vertical rectus abdominis myocutaneous (VRAM) flap for pelvic reconstruction after total pelvic exenteration.International journal of colorectal disease · 2014Article
- Enhancing mandibular bone regeneration and perfusion via axial vascularization of scaffolds.Clinical oral investigations · 2014Article
- Stromal-epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands.Journal of cellular and molecular medicine · 2014Article
- Successful human long-term application of in situ bone tissue engineering.Journal of cellular and molecular medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue Engineering (TE) in the context of Regenerative Medicine (RM) has been hailed for many years as one of the most important topics in medicine in the twenty-first century. While the first clinically relevant TE efforts were mainly concerned with the generation of bioengineered skin substitutes, subsequently TE applications have been continuously extended to a wide variety of tissues and organs. The advent of either embryonic or mesenchymal adult stem-cell technology has fostered many of the efforts to combine this promising tool with TE approaches and has merged the field into the term Regenerative Medicine. As a typical example in translational medicine, the discovery of a new type of cells called Telocytes that have been described in many organs and have been detected by electron microscopy opens another gate to RM. Besides cell-therapy strategies, the application of gene therapy combined with TE has been investigated to generate tissues and organs. The vascularization of constructs plays a crucial role besides the matrix and cell substitutes. Therefore, novel in vivo models of vascularization have evolved allowing axial vascularization with subsequent transplantation of constructs. This article is intended to give an overview over some of the most recent developments and possible applications in RM through the perspective of TE achievements and cellular research. The synthesis of TE with innovative methods of molecular biology and stem-cell technology appears to be very promising.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.