ArticleMolecular microbiology2012
Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites.PLoS biology · 2021Article
- Article
- Article
- PfMAP-2 is essential for male gametogenesis in the malaria parasite Plasmodium falciparum.Scientific reports · 2020Article
- Rapid activation of distinct members of multigene families in Plasmodium spp.Communications biology · 2020Article
- A single-nucleotide polymorphism in aScience advances · 2020Article
- Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum.Scientific reports · 2019Article
- Independent regulation of Plasmodium falciparum rif gene promoters.Scientific reports · 2018Article
- GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing.Science (New York, N.Y.) · 2018Article
- Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan.Scientific reports · 2018Article
- An ApiAP2 member regulates expression of clonally variant genes of the human malaria parasite Plasmodium falciparum.Scientific reports · 2017Article
- Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa.Cell host & microbe · 2016Review
- Deciphering the principles that govern mutually exclusive expression of Plasmodium falciparum clag3 genes.Nucleic acids research · 2015Article
- Advances in genetics and genomics: use and limitations in achieving malaria elimination goals.Pathogens and global health · 2015Review
- The conserved clag multigene family of malaria parasites: essential roles in host-pathogen interaction.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2015Review
- A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparum.PloS one · 2014Article
- Lateral gene transfer of family A DNA polymerases between thermophilic viruses, aquificae, and apicomplexa.Molecular biology and evolution · 2013Article
- Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum.Cellular microbiology · 2012Article
- Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum.Genome biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Plasmodium falciparum genome is equipped with several subtelomeric gene families that are implicated in parasite virulence and immune evasion. Members of these families are uniformly positioned within heterochromatic domains and are thus subject to variegated expression. The best-studied example is that of the var family encoding the major parasite virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 undergoes antigenic variation through switches in mutually exclusive var gene transcription. var promoters function as crucial regulatory elements in the underlying epigenetic control strategy. Here, we analysed promoters of upsA, upsB and upsC var, rifA1-type rif, stevor, phist and pfmc-2tm genes and investigated their role in endogenous gene transcription by comparative genome-wide expression profiling of transgenic parasite lines. We find that the three major var promoter types are functionally equal and play an essential role in singular gene choice. Unlike var promoters, promoters of non-var families are not silenced by default, and transcription of non-var families is not subject to the same mode of mutually exclusive transcription as has been observed for var genes. Our findings identified a differential logic in the regulation of var and other subtelomeric virulence gene families, which will have important implications for our understanding and future analyses of phenotypic variation in malaria parasites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.