ArticleJournal of cellular and molecular medicine2012
Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterine myocytes.
Article in Journal of cellular and molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- The Effect of Circulating Proteins and Their Role in Mediating Adiposity's Effect on Endometrial Cancer Risk: Mendelian Randomization and Colocalization Analyses.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- The zinc-finger transcription factor Blimp1/Prdm1 is required for uterine remodelling and repair in the mouse.Nature communications · 2025Article
- Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling.Molecular and cellular biochemistry · 2024Article
- Factors of Fetal Origin in the Regulation of Labor Initiation and Preterm Birth.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Is human labor at term an inflammatory condition?†.Biology of reproduction · 2023Review
- Molecular Mechanism of Mouse Uterine Smooth Muscle Regulation on Embryo Implantation.International journal of molecular sciences · 2022Article
- Differential Expression of CBCannabis and cannabinoid research · 2022Article
- Nuclear Receptors in Pregnancy and Outcomes: Clinical Perspective.Advances in experimental medicine and biology · 2022Article
- Dynamic transcriptome, accessible genome, and PGR cistrome profiles in the human myometrium.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism.Obstetrics & gynecology science · 2019Review
- Differential expression of progesterone receptor isoforms related toInternational journal of reproductive biomedicine · 2019Article
- The transcriptional repressor GATAD2B mediates progesterone receptor suppression of myometrial contractile gene expression.The Journal of biological chemistry · 2017Article
- Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns.Clinical epigenetics · 2017Article
- The role of sex steroid hormones in the pathophysiology and treatment of sarcopenia.Osteoporosis and sarcopenia · 2016Review
- Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition.Human reproduction update · 2016Review
- The study of progesterone action in human myometrial explants.Molecular human reproduction · 2016Article
- Modeling hormonal and inflammatory contributions to preterm and term labor using uterine temporal transcriptomics.BMC medicine · 2016Article
- Progesterone and the Repression of Myometrial Inflammation: The Roles of MKP-1 and the AP-1 System.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Article
- Molecular Regulation of Parturition: A Myometrial Perspective.Cold Spring Harbor perspectives in medicine · 2015Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The absence of a fall in circulating progesterone levels has led to the concept that human labour is associated with 'functional progesterone withdrawal' caused through changes in the expression or function of progesterone receptor (PR). At the time of labour, the human uterus is heavily infiltrated with inflammatory cells, which release cytokines to create a 'myometrial inflammation' via NF-κB activation. The negative interaction between NF-κB and PR, may represent a mechanism to account for 'functional progesterone withdrawal' at term. Conversely, PR may act to inhibit NF-κB function and so play a role in inhibition of myometrial inflammation during pregnancy. To model this inter-relationship, we have used small interfering (si) RNA-mediated knock-down of PR in human pregnant myocytes and whole genome microarray analysis to identify genes regulated through PR. We then activated myometrial inflammation using IL-1β stimulation to determine the role of PR in myometrial inflammation regulation. Through PR-knock-down, we found that PR regulates gene networks involved in myometrial quiescence and extracellular matrix integrity. Activation of myometrial inflammation was found to antagonize PR-induced gene expression, of genes normally upregulated via PR. We found that PR does not play a role in repression of pro-inflammatory gene networks induced by IL-1β and that only MMP10 was significantly regulated in opposite directions by IL-1β and PR. We conclude that progesterone acting through PR does not generally inhibit myometrial inflammation. Activation of myometrial inflammation does cause 'functional progesterone withdrawal' but only in the context of genes normally upregulated via PR.
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