ArticleTherapeutic advances in neurological disorders2012
Neuroimaging of motor neuron diseases.
Article in Therapeutic advances in neurological disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Potential Roles of Neuroimaging in Motor Neuron Disease.Current neurology and neuroscience reports · 2026Review
- Neurofilaments support the differentiation of amyotrophic lateral sclerosis from degenerative cervical myelopathy.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Subcortical microstructural impairment in amyotrophic lateral sclerosis: clinical correlates of neurite orientation dispersion and density imaging (NODDI) changes.Frontiers in neuroscience · 2026Article
- Mapping motor and extra-motor gray and white matter changes in ALS: a comprehensive review of MRI insights.Neuroradiology · 2025Review
- Segmental involvement of the corpus callosum inTherapeutic advances in chronic disease · 2021Article
- Focal alterations of the callosal area III in primary lateral sclerosis: An MRI planimetry and texture analysis.NeuroImage. Clinical · 2020Article
- Role of Magnetic Resonance Imaging in Diagnosis of Motor Neuron Disease: Literature Review and Two Case Illustrations.The Permanente journal · 2019Review
- Amyotrophic Lateral Sclerosis and its Mimics/Variants: A Comprehensive Review.Journal of clinical imaging science · 2018Review
- Investigating white matter fibre density and morphology using fixel-based analysis.NeuroImage · 2017Article
- Microstructural changes across different clinical milestones of disease in amyotrophic lateral sclerosis.PloS one · 2015Article
- Brain white matter involvement in hereditary spastic paraplegias: analysis with multiple diffusion tensor indices.AJNR. American journal of neuroradiology · 2014Article
- Lessons of ALS imaging: Pitfalls and future directions - A critical review.NeuroImage. Clinical · 2014Review
- Diffusion tensor magnetic resonance imaging in the analysis of neurodegenerative diseases.Journal of visualized experiments : JoVE · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is agreed that conventional magnetic resonance imaging (MRI) of the brain and spine is one of the core elements in the differential diagnostic work up of patients with clinical signs of motor neuron diseases (MNDs), for example amyotrophic lateral sclerosis (ALS), to exclude MND mimics. However, the sensitivity and specificity of MRI signs in these disorders are moderate to low and do not have an evidence level higher than class IV (good clinical practice point). Currently computerized MRI analyses in ALS and other MNDs are not techniques used for individual diagnosis. However, they have improved the anatomical understanding of pathomorphological alterations in gray and white matter in various MNDs and the changes in functional networks by quantitative comparisons between patients with MND and controls at group level. For multiparametric MRI protocols, including T1-weighted three-dimensional datasets, diffusion-weighted imaging and functional MRI, the potential as a 'dry' surrogate marker is a subject of investigation in natural history studies with well defined patients. The additional value of MRI with respect to early diagnosis at an individual level and for future disease-modifying multicentre trials remains to be defined. There is still the need for more longitudinal studies in the very early stages of disease or when there is clinical uncertainty and for better standardization in the acquisition and postprocessing of computer-based MRI data. These requirements are to be addressed by establishing quality-controlled multicentre neuroimaging databases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.