ArticleTherapeutic advances in neurological disorders2012
Health-related quality of life as an outcome variable in Parkinson's disease.
Article in Therapeutic advances in neurological disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Effects of different exercises on motor and non-motor abilities in patients with Parkinson disease-a network meta-analysis of randomized controlled trials.Frontiers in physiology · 2026Pooled it
- The use and impact of quality of life assessment tools in clinical care settings for cancer patients, with a particular emphasis on brain cancer: insights from a systematic review and stakeholder consultations.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Pooled it
- Psychological Factors Affecting Assertiveness in Subjects with Parkinson's Disease.Journal of clinical medicine · 2024Article
- The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania.Diagnostics (Basel, Switzerland) · 2024Article
- Gender gap in deep brain stimulation for Parkinson's disease: preliminary results of a retrospective study.Neurosurgical review · 2024Article
- Staging Parkinson's Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Life.Journal of Parkinson's disease · 2023Article
- Predictors of clinically significant quality of life impairment in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Predictors of short-term impulsive and compulsive behaviour after subthalamic stimulation in Parkinson disease.Journal of neurology, neurosurgery, and psychiatry · 2021Article
- Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson's Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up.Journal of personalized medicine · 2021Article
- Factors Associated with Health-Related Quality of Life in Late-Stage Parkinson's Disease.Movement disorders clinical practice · 2021Article
- Rehabilitation of Falls in Parkinson's Disease: Self-Perception vs. Objective Measures of Fall Risk.Brain sciences · 2021Article
- Relationship Dynamics of Couples Facing Advanced-Stage Parkinson's Disease: A Dyadic Interpretative Phenomenological Analysis.Frontiers in psychology · 2021Article
- Radiosynthesis and evaluation of 4-(6-[RSC medicinal chemistry · 2020Article
- Interpretation of health-related quality of life outcomes in Parkinson's disease from the EARLYSTIM Study.PloS one · 2020Article
- A Review of Scales to Evaluate Sleep Disturbances in Movement Disorders.Frontiers in neurology · 2018Review
- Article
- Bayesian multivariate augmented Beta rectangular regression models for patient-reported outcomes and survival data.Statistical methods in medical research · 2017Article
- Use of the World Health Organization Quality of Life Assessment Short Version in Mild to Moderate Parkinson Disease.Archives of physical medicine and rehabilitation · 2016Article
- What Should Constitute a Health Related Quality of Life Scale for Parkinson's Disease?Journal of clinical and diagnostic research : JCDR · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past three decades, health-related quality of life (HRQoL) has become an outcome variable in Parkinson's disease clinical trials. This review considers the measuring tools that have been developed, suitability of data reporting, complexity of outcome interpretation, and clinical application to provide evidence regarding available therapeutic interventions to date. In the introduction, different terms regarding quality of life are clearly defined. The methodology section offers an overview of generic, disease specific, and recommended HRQoL scales in Parkinson's disease and the most important psychometric attributes a scale should meet. The interpretation of HRQoL outcomes is complex and not intuitive. Thus, appropriate reporting of data is crucial in order to calculate relative change, a result that facilitates understanding to what extent an intervention is beneficial. The concept of minimally important change/difference is explained as well as the different approaches to its calculation (anchor-based and distribution-based methods). In the results section, a brief overview of the impact on HRQoL of currently available treatments in Parkinson's disease is provided. Special emphasis is given to data assessment, highlighting reports that helped understanding of the clinical significance of the intervention and therefore aided in making therapeutic decisions. The discussion section emphasizes the need for more clinical trials with HRQoL as a primary outcome and standardized reporting in order to further our understanding of the complexity of treatment effects and make evidence-based clinical decisions regarding HRQoL in patients with Parkinson's disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.