ArticleTherapeutic advances in neurological disorders2012
Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis?
Article in Therapeutic advances in neurological disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of non-invasive brain stimulation on balance control in patients with multiple sclerosis: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Systematic Review on Exercise Training as a Neuroplasticity-Inducing Behavior in Multiple Sclerosis.Neurorehabilitation and neural repair · 2020Pooled it
- Altered muscle oxidative phenotype impairs exercise tolerance but does not improve after exercise training in multiple sclerosis.Journal of cachexia, sarcopenia and muscle · 2022Trial
- Does aerobic training alleviate fatigue and improve societal participation in patients with multiple sclerosis? A randomized controlled trial.Multiple sclerosis (Houndmills, Basingstoke, England) · 2017Trial
- Effects of a Short Physical Exercise Intervention on Patients with Multiple Sclerosis (MS).International journal of molecular sciences · 2015Trial
- Trial
- Mindfulness-based interventions in multiple sclerosis: beneficial effects of Tai Chi on balance, coordination, fatigue and depression.BMC neurology · 2014Trial
- Trial
- Exercise and Ferroptosis in Neurodegenerative Diseases: Direct Evidence, Mechanistic Links, and Translational Gaps.International journal of molecular sciences · 2026Review
- Scaling up an Evidence-Based Exercise Intervention for Wide-Scale Implementation: A Conceptual Roadmap Using the PRACTIS Framework.Healthcare (Basel, Switzerland) · 2026Article
- Steps to Health: Backward Walking Predicts Physical Activity Levels in Multiple Sclerosis.Neurorehabilitation and neural repair · 2026Article
- Feasibility and Pre-Post Changes Associated with a 12-Week Treadmill Walking Training Programme on Walking Performance, Physical Function, Fatigue, and Quality of Life in People with Multiple Sclerosis: A Single-Arm Pilot Study.Healthcare (Basel, Switzerland) · 2026Article
- Beneficial impact of physical activity on multiple sclerosis disability progression.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Physical Therapists' Use of Behavior Change Strategies to Promote Physical Activity for Individuals with Neurological Conditions.Healthcare (Basel, Switzerland) · 2025Article
- Impact of Age on Switching or Stopping Disease Modifying Therapies in Multiple Sclerosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Predicting Real-World Physical Activity in Multiple Sclerosis: An Integrated Approach Using Clinical, Sensor-Based, and Self-Reported Measures.Sensors (Basel, Switzerland) · 2025Article
- Exploring Perceptions of Physical Activity in Individuals Newly Diagnosed with Multiple Sclerosis.Journal of clinical medicine · 2025Article
- The Compelling Role of Brain-Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators.CNS neuroscience & therapeutics · 2024Review
- Management of multiple sclerosis in older adults: review of current evidence and future perspectives.Journal of neurology · 2024Review
- Utilizing Aerobic Capacity Data for EDSS Score Estimation in Multiple Sclerosis: A Machine Learning Approach.Diagnostics (Basel, Switzerland) · 2024Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been suggested that exercise (or physical activity) might have the potential to have an impact on multiple sclerosis (MS) pathology and thereby slow down the disease process in MS patients. The objective of this literature review was to identify the literature linking physical exercise (or activity) and MS disease progression. A systematic literature search was conducted in the following databases: PubMed, SweMed+, Embase, Cochrane Library, PEDro, SPORTDiscus and ISI Web of Science. Different methodological approaches to the problem have been applied including (1) longitudinal exercise studies evaluating the effects on clinical outcome measures, (2) cross-sectional studies evaluating the relationship between fitness status and MRI findings, (3) cross-sectional and longitudinal studies evaluating the relationship between exercise/physical activity and disability/relapse rate and, finally, (4) longitudinal exercise studies applying the experimental autoimmune encephalomyelitis (EAE) animal model of MS. Data from intervention studies evaluating disease progression by clinical measures (1) do not support a disease-modifying effect of exercise; however, MRI data (2), patient-reported data (3) and data from the EAE model (4) indicate a possible disease-modifying effect of exercise, but the strength of the evidence limits definite conclusions. It was concluded that some evidence supports the possibility of a disease-modifying potential of exercise (or physical activity) in MS patients, but future studies using better methodologies are needed to confirm this.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.