ArticleFrontiers in genetics2012
The metamorphosis of amphibian toxicogenomics.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Framework for multi-stressor physiological response evaluation in amphibian risk assessment and conservation.Frontiers in ecology and evolution · 2024Article
- Using metabolomic profiling to inform use of surrogate species in ecological risk assessment practices.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2022Article
- Blood biomarkers of common toadInterdisciplinary toxicology · 2018Article
- Unexpected metabolic disorders induced by endocrine disruptors inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- The North American bullfrog draft genome provides insight into hormonal regulation of long noncoding RNA.Nature communications · 2017Article
- Survival and development of bullfrog tadpoles in microcosms treated with abamectin.Ecotoxicology (London, England) · 2017Article
- An Aryl Hydrocarbon Receptor from the Salamander Ambystoma mexicanum Exhibits Low Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin.Environmental science & technology · 2015Article
- Article
- The spring runoff in Nebraska's (USA) Elkhorn River watershed and its impact on two sentinel organisms.Environmental toxicology and chemistry · 2013Article
- Toxicogenomics in non-mammalian species-Editorial.Frontiers in genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amphibians are important vertebrates in toxicology often representing both aquatic and terrestrial forms within the life history of the same species. Of the thousands of species, only two have substantial genomics resources: the recently published genome of the Pipid, Xenopus (Silurana) tropicalis, and transcript information (and ongoing genome sequencing project) of Xenopus laevis. However, many more species representative of regional ecological niches and life strategies are used in toxicology worldwide. Since Xenopus species diverged from the most populous frog family, the Ranidae, ~200 million years ago, there are notable differences between them and the even more distant Caudates (salamanders) and Caecilians. These differences include genome size, gene composition, and extent of polyploidization. Application of toxicogenomics to amphibians requires the mobilization of resources and expertise to develop de novo sequence assemblies and analysis strategies for a broader range of amphibian species. The present mini-review will present the advances in toxicogenomics as pertains to amphibians with particular emphasis upon the development and use of genomic techniques (inclusive of transcriptomics, proteomics, and metabolomics) and the challenges inherent therein.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.