ArticleFrontiers in behavioral neuroscience2012
Involvement of the insular cortex in regulating glucocorticoid effects on memory consolidation of inhibitory avoidance training.
Article in Frontiers in behavioral neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- The infralimbic mineralocorticoid blockage prevents the stress-induced impairment of aversive memory extinction in rats.Translational psychiatry · 2022Article
- Basolateral amygdala activation enhances object recognition memory by inhibiting anterior insular cortex activity.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Remote contextual fear retrieval engages activity from salience network regions in rats.Neurobiology of stress · 2022Article
- Morning blue light treatment improves sleep complaints, symptom severity, and retention of fear extinction memory in post-traumatic stress disorder.Frontiers in behavioral neuroscience · 2022Article
- Central stress processing, T-cell responsivity to stress hormones and disease severity in multiple sclerosis.Brain communications · 2022Article
- Prefrontal cortex PACAP signaling: organization and role in stress regulation.Stress (Amsterdam, Netherlands) · 2021Article
- Glucocorticoid enhancement of recognition memory via basolateral amygdala-driven facilitation of prelimbic cortex interactions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Role of the Rodent Insula in Anxiety.Frontiers in physiology · 2019Article
- Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation.Neuroendocrinology · 2019Review
- Altered fear processing in adolescents with a history of severe childhood maltreatment: an fMRI study.Psychological medicine · 2018Article
- Stress, glucocorticoids and memory: implications for treating fear-related disorders.Nature reviews. Neuroscience · 2017Review
- Mushroom spine dynamics in medium spiny neurons of dorsal striatum associated with memory of moderate and intense training.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The influence of self-awareness on emotional memory formation: an fMRI study.Social cognitive and affective neuroscience · 2016Article
- Brain glucose metabolism is associated with hormone level in Cushing's disease: A voxel-based study using FDG-PET.NeuroImage. Clinical · 2016Article
- The inhibitory avoidance discrimination task to investigate accuracy of memory.Frontiers in behavioral neuroscience · 2015Article
- Noradrenergic activation of the basolateral amygdala enhances object recognition memory and induces chromatin remodeling in the insular cortex.Frontiers in behavioral neuroscience · 2015Article
- Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: from adaptive responses to psychopathologies.Neurobiology of learning and memory · 2014Review
- Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats.PloS one · 2014Article
- Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucocorticoids are known to enhance the consolidation of memory of emotionally arousing experiences by acting upon a network of interconnected brain regions. Although animal studies typically do not consider the insular cortex (IC) to be part of this network, the present findings indicate that the IC is importantly involved in regulating glucocorticoid effects on memory consolidation of emotionally arousing inhibitory avoidance training. The specific glucocorticoid receptor (GR) agonist RU 28362 (3 or 10 ng in 0.5 μl) infused bilaterally into the IC of male Sprague-Dawley rats immediately after one-trial inhibitory avoidance training dose-dependently enhanced 48 h retention performance. Moreover, training on the inhibitory avoidance task increased neuronal activity of the IC, as assessed by an increased number of cells expressing immunoreactivity for phosphorylated extracellular signal-regulated kinase 1/2 (pERK1/2). However, systemic administration of a memory-enhancing dose of corticosterone (1 mg/kg) after inhibitory avoidance training rapidly reduced the number of pERK1/2-positive cells in the IC, suggesting that glucocorticoid administration reduces overall neuronal activity of the IC. To investigate which components of the inhibitory avoidance training experience were influenced by the intra-IC glucocorticoid administration, in the last experiment rats were trained on a modified inhibitory avoidance task in which context exposure and footshock training occur on two sequential days. RU 28362 administration into the IC enhanced later retention when infused immediately after either the context or footshock training. Thus, these findings indicate that the IC mediates glucocorticoid effects on the consolidation of memory of different components of inhibitory avoidance training and suggest that the IC might be an important element of the rodent brain network involved in emotional regulation of learning and memory.
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