ArticleNucleic acids research2012
Phase variable genes of Campylobacter jejuni exhibit high mutation rates and specific mutational patterns but mutability is not the major determinant of population structure during host colonization.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 92 citations in OpenAlex.
- Article
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- 100+ years of phase variation: the premier bacterial bet-hedging phenomenon.Microbiology (Reading, England) · 2025Review
- Understanding prokaryotic adaptation through advanced DNA methylation detection techniques.The ISME journal · 2025Review
- A hybrid receptor binding protein enables phage F341 infection ofFrontiers in microbiology · 2024Article
- Bifunctional Epimerase/Reductase Enzymes Facilitate the Modulation of 6-Deoxy-Heptoses Found in the Capsular Polysaccharides ofBiochemistry · 2023Article
- Comparative genomics of Campylobacter jejuni from clinical campylobacteriosis stool specimens.Gut pathogens · 2022Article
- Product Specificity of C4-Reductases in the Biosynthesis of GDP-6-Deoxy-Heptoses during Capsular Polysaccharide Formation inBiochemistry · 2022Article
- Article
- Evolutionary Dynamics between Phages and Bacteria as a Possible Approach for Designing Effective Phage Therapies against Antibiotic-Resistant Bacteria.Antibiotics (Basel, Switzerland) · 2022Review
- Metaphenotypes associated with recurrent genomic lineages ofFrontiers in microbiology · 2022Article
- Functional Characterization of Two PLP-Dependent Enzymes Involved in Capsular Polysaccharide Biosynthesis fromBiochemistry · 2021Article
- Article
- How does feedback from phage infections influence the evolution of phase variation in Campylobacter?PLoS computational biology · 2021Article
- Antibiotic Resistance in the Alternative Lifestyles ofFrontiers in cellular and infection microbiology · 2021Article
- Identification of Novel Phage Resistance Mechanisms inFrontiers in microbiology · 2021Article
- Phase Variation During Host Colonization and Invasion byFrontiers in microbiology · 2021Review
- Meningococcal core and accessory phasomes vary by clonal complex.Microbial genomics · 2020Article
- Campylobacter jejuni and Campylobacter coli autotransporter genes exhibit lineage-associated distribution and decay.BMC genomics · 2020Article
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11 authors at 2 institutions in 1 country.
Funding
Abstract
Phase variation of surface structures occurs in diverse bacterial species due to stochastic, high frequency, reversible mutations. Multiple genes of Campylobacter jejuni are subject to phase variable gene expression due to mutations in polyC/G tracts. A modal length of nine repeats was detected for polyC/G tracts within C. jejuni genomes. Switching rates for these tracts were measured using chromosomally-located reporter constructs and high rates were observed for cj1139 (G8) and cj0031 (G9). Alteration of the cj1139 tract from G8 to G11 increased mutability 10-fold and changed the mutational pattern from predominantly insertions to mainly deletions. Using a multiplex PCR, major changes were detected in 'on/off' status for some phase variable genes during passage of C. jejuni in chickens. Utilization of observed switching rates in a stochastic, theoretical model of phase variation demonstrated links between mutability and genetic diversity but could not replicate observed population diversity. We propose that modal repeat numbers have evolved in C. jejuni genomes due to molecular drivers associated with the mutational patterns of these polyC/G repeats, rather than by selection for particular switching rates, and that factors other than mutational drift are responsible for generating genetic diversity during host colonization by this bacterial pathogen.
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