ArticleNucleic acids research2012
Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Modulation of RNA stability regulates gene expression in two opposite ways: through buffering of RNA levels upon global perturbations and by supporting adapted differential expression.Nucleic acids research · 2022Article
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- A Novel Calibration Step in Gene Co-Expression Network Construction.Frontiers in bioinformatics · 2021Article
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- RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation.PLoS genetics · 2018Article
- Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains.Epigenetics & chromatin · 2018Article
- CRISPR/Cas9-induced monoallelic mutations in the cytosolic AGPase large subunit gene APL2 induce the ectopic expression of APL2 and the corresponding small subunit gene APS2b in rice leaves.Transgenic research · 2018Article
- The X-linked 1.688 Satellite inGenetics · 2018Article
- Effects of Gene Dose, Chromatin, and Network Topology on Expression in Drosophila melanogaster.PLoS genetics · 2016Article
- Dosage compensation of the sex chromosomes and autosomes.Seminars in cell & developmental biology · 2016Review
- Genome-Wide Gene/Genome Dosage Imbalance Regulates Gene Expressions in SyntheticFrontiers in plant science · 2016Article
- Proximity ligation assays of protein and RNA interactions in the male-specific lethal complex on Drosophila melanogaster polytene chromosomes.Chromosoma · 2015Article
- X Chromosome and Autosome Dosage Responses in Drosophila melanogaster Heads.G3 (Bethesda, Md.) · 2015Article
- Increased expression of X-linked genes in mammals is associated with a higher stability of transcripts and an increased ribosome density.Genome biology and evolution · 2015Article
- Negative feedback buffers effects of regulatory variants.Molecular systems biology · 2015Article
- Non-coding roX RNAs prevent the binding of the MSL-complex to heterochromatic regions.PLoS genetics · 2014Article
- DNA copy number evolution in Drosophila cell lines.Genome biology · 2014Article
- Transcriptional effects of gene dose reduction.Biology of sex differences · 2014Article
- Male X-linked genes in Drosophila melanogaster are compensated independently of the Male-Specific Lethal complex.Epigenetics & chromatin · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Variation in the number of individual chromosomes (chromosomal aneuploidy) or chromosome segments (segmental aneuploidy) is associated with developmental abnormalities and reduced fitness in all species examined; it is the leading cause of miscarriages and mental retardation and a hallmark of cancer. However, despite their documented importance in disease, the effects of aneuploidies on the transcriptome remain largely unknown. We have examined the expression effects of seven heterozygous chromosomal deficiencies, both singly and in all pairwise combinations, in Drosophila melanogaster. The results show that genes in one copy are buffered, i.e. expressed more strongly than the expected 50% of wild-type level, the buffering is general and not influenced by other monosomic regions. Furthermore, long genes are significantly more highly buffered than short genes and gene length appears to be the primary determinant of the buffering degree. For short genes the degree of buffering depends on expression level and expression pattern. Furthermore, the results show that in deficiency heterozygotes the expression of genes involved in proteolysis is enhanced and negatively correlates with the degree of buffering. Thus, enhanced proteolysis appears to be a general response to aneuploidy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.