ArticlePediatric obesity2012
Birth weight, early weight gain and pubertal maturation: a longitudinal study.
Article in Pediatric obesity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- The association between birth weight/rapid weight gain and early menarche: a systematic review and meta-analysis based on cohort studies.BMC pediatrics · 2025Pooled it
- Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review.European journal of endocrinology · 2021Pooled it
- Association of prenatal and childhood environment smoking exposure with puberty timing: a systematic review and meta-analysis.Environmental health and preventive medicine · 2018Pooled it
- Nongenetic determinants of age at menarche: a systematic review.BioMed research international · 2014Pooled it
- Association of Infant Physical Development and Rapid Growth With Pubertal Onset Among Girls in Rural China.JAMA network open · 2021Trial
- Early Postnatal Growth and Pubertal Timing: An Ultrasound-Based Study of Breast and Testicular Development.Journal of the Endocrine Society · 2026Article
- Puberty, but not precocious puberty is influenced by weight gain in the first years of life.Endocrine · 2025Article
- Associations of fetal and infant growth with pubertal timing.Archives of disease in childhood · 2025Article
- The role of adipose tissue in puberty and reproductive health.Frontiers in endocrinology · 2025Review
- Impact of Small-Quantity Lipid-Based Nutrient Supplements on Pubertal Status of 9-13-Year Olds: A Follow-Up Study of the iLiNS-DYAD-Ghana Trial.Current developments in nutrition · 2024Article
- Maternal Adverse Childhood Experiences and Biological Aging During Pregnancy and in Newborns.JAMA network open · 2024Article
- Pubertal timing: A life course pathway linking early life risk to adulthood cardiometabolic health.PloS one · 2024Article
- Phenotyping children and adolescents with obesity using behavioral, psychological, and familial data.Obesity (Silver Spring, Md.) · 2023Article
- Maternal cafeteria diet influences kisspeptin (Kiss1), kisspeptin receptor(Gpr54), and sirtuin (Sirt1) genes, hormonal and metabolic profiles, and reproductive functions in rat offspring in a sex-specific manner†.Biology of reproduction · 2023Article
- Advances for pediatricians in 2022: allergy, anesthesiology, cardiology, dermatology, endocrinology, gastroenterology, genetics, global health, infectious diseases, metabolism, neonatology, neurology, oncology, pulmonology.Italian journal of pediatrics · 2023Review
- Maternal and prenatal factors and age at thelarche in the LEGACY Girls Study cohort: implications for breast cancer risk.International journal of epidemiology · 2023Article
- Rapid weight gain in early life is associated with central precocious puberty in girls, not in boys - a nationwide population-based study in Korea.Frontiers in endocrinology · 2023Article
- Associations between infant growth and pubertal onset timing in a multiethnic prospective cohort of girls.BMC pediatrics · 2022Article
- Retrospective longitudinal analysis of the effects of postnatal weight gain on the timing and tempo of puberty and menarche in a cohort of Italian girls.Italian journal of pediatrics · 2022Article
- Analysis of Early-Life Growth and Age at Pubertal Onset in US Children.JAMA network open · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate the effect of birth weight and early weight gain on the timing of various measures of puberty in both girls and boys.
methodsA total of 856 newborns enrolled in the North Carolina Infant Feeding Study were followed to age 5 years, with 600 children followed up at adolescence. Birth weight was obtained from medical records and children were weighed at study visits until age 5 years; gains in standardized weights were calculated over four early age intervals: 0-6 months, 6-12 months, 1-2 years and 2-5 years. Age at menarche in girls and age at advanced Tanner stages in both girls and boys were reported by adolescents and their parents. Survival models were used to analyse the effects of birth weight and early weight gain on these outcomes.
resultsGirls with higher birth weight and greater weight gains during the four early age intervals were younger when they reached menarche and advanced Tanner stages; boys with greater early weight gains also were younger when they reached advanced Tanner stages, but few of these effects were statistically significant.
conclusionsHigher birth weights and greater weight gains during infancy and early childhood can lead to earlier sexual maturation in girls.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.