Evidence map›Paper›PMID 22434719›Full record

ArticlePediatric blood & cancer2013

Epidemiology of rhabdoid tumors of early childhood.

Julia E Heck, Christina A Lombardi, Myles Cockburn, Travis J Meyers, Michelle Wilhelm, Beate Ritz

Open access · greenAbstract read
In one paragraph

Article in Pediatric blood & cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 76 citations in OpenAlex.

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  5. Childhood Cancer Risk in Hispanic Enclaves in California.Journal of immigrant and minority health · 2025
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  14. Prenatal Exposure to Air Toxics and Malignant Germ Cell Tumors in Young Children.Journal of occupational and environmental medicine · 2019
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Julia E HeckDepartment of Epidemiology, School of Public Health, University of California, Los Angeles, CA, USA. jeheck@ucla.edu
Christina A Lombardi
Myles Cockburn
Travis J Meyers
Michelle Wilhelm
Beate Ritz
University of California, Los Angeles · USUCLA Health · USUniversity of Southern California · US

Funding

UCLA Career Development Program in Cancer Prevention and Control ResearchR25CA087949 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BASTANI, ROSHAN · 2000 to 2014
$6.8M
Air Pollution and Childhood Cancers in CaliforniaR21ES018960 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2010 to 2011
$421k
Pesticide Exposure and Childhood Cancer StudyR21ES019986 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2011 to 2012
$409k
Parental Occupation and Childhood CancersR03ES021643 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2012 to 2013
$152k
NCI NIH HHS R25 CA087949NIEHS NIH HHS R03 ES021643NIEHS NIH HHS R21 ES018960NIEHS NIH HHS R21ES018960NIEHS NIH HHS R21 ES019986NIEHS NIH HHS R21ES019986
6 · The paper itself

Abstract

backgroundRhabdoid tumors are a rare and aggressive cancer subtype which is usually diagnosed in early childhood. Little is known about their etiology. The purpose of this study was to describe the epidemiology of rhabdoid tumors and examine their relation to perinatal characteristics.

methodsWe identified 44 atypical teratoid/rhabdoid tumors (AT/RT) of the central nervous system (CNS) and 61 rhabdoid sarcomas (renal and extra-renal non-CNS tumors) from California Cancer Registry records of diagnoses 1988-2007 among children <6 years of age. We randomly selected 208,178 controls from California birthrolls. Multivariable logistic regression was used to examine associations between rhabdoid tumors and perinatal characteristics.

resultsAfter adjustment for demographic characteristics, low birthweight (<2,500 g) strongly increased risk for developing both rhabdoid sarcomas (OR = 2.43, 95% CI 1.09, 5.41) and AT/RT (OR = 2.99, 95% CI 1.31, 6.84). Both preterm delivery (<37 weeks gestation, OR = 2.63, 95% CI 1.34, 5.17) and late term delivery (>42 weeks, OR = 3.66, 95% CI 1.54, 8.71) also increased risk of rhabdoid sarcomas. Rhabdoid sarcoma cases (OR = 3.08, 95% CI 1.11, 8.55) and AT/RT cases (OR = 3.16, 95% CI 1.23, 8.13) also were more likely to be multiple births.

conclusionThe excess of twin pregnancies may suggest an association with infertility treatments. This is the first population-based epidemiologic study to examine these rare tumors.

Indexed as

AdultChild, PreschoolFemaleHumansInfantInfant, NewbornLogistic ModelsMalePregnancyRhabdoid Tumor

Identifiers

PMID22434719
PMCPMC3399923
OpenAlexW2140290389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.